Art

J-GLOBAL ID：201802236403912328   Reference number：18A1010932

Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis

p62遺伝子およびNrf2遺伝子両方の欠失は非アルコール性脂肪肝炎を自然発症する

Author (15)： Akiyama Kentaro (Doctoral Programs in Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan) ,  Akiyama Kentaro (Japan Society for the Promotion of Science, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan) ,  Warabi Eiji (Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan) ,  Okada Kosuke (Division of Gastroenterology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan) ,  Yanagawa Toru (Division of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan) ,  Ishii Tetsuro (Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan) ,  Kose Katsumi (Institute of Applied Physics, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8573, Japan) ,  Tokushige Katsutoshi (Institute of Gastroenterology Internal Medicine, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan) ,  Ishige Kazunori (Division of Gastroenterology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan) ,  Mizokami Yuji (Division of Gastroenterology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan) ,  Yamagata Kenji (Division of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan) ,  Onizawa Kojiro (Division of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan) ,  Ariizumi Shun-ichi (Institute of Gastroenterology Surgery, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan) ,  Yamamoto Masakazu (Institute of Gastroenterology Surgery, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan) ,  Shoda Junichi (Medical Sciences, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan)
Material： Experimental Animals  (実験動物ニュース)
Volume： 67  Issue： 2  Page： 201-218(J-STAGE)  Publication year： 2018 
JST Material Number： Z0755A  ISSN： 1341-1357  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： knockout mouse ,...
Semi thesaurus term： Nrf2遺伝子 ,...

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Author keywords (5)： dysbiosis ,  hyperphagia ,  intestinal permeability ,  lipopolysaccharide ,  multiple parallel hits hypothesis

JST classification (2)： Basic medicine on digestive system  (GH01020E) ,  Immunological reaction in general  (ED03010T)

Reference (47)：

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• 3. Bugianesi E., Leone N., Vanni E., Marchesini G., Brunello F., Carucci P., Musso A., De Paolis P., Capussotti L., Salizzoni M., and Rizzetto M. 2002. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 123: 134-140.
• 4. Chitturi S. and Farrell G.C. 2001. Etiopathogenesis of nonalcoholic steatohepatitis. Semin. Liver Dis. 21: 27-41.
• 5. Cong L., Ran F.A., Cox D., Lin S., Barretto R., Habib N., Hsu P.D., Wu X., Jiang W., Marraffini L.A., and Zhang F. 2013. Multiplex genome engineering using CRISPR/Cas systems. Science 339: 819-823.

Terms in the title (6)： p62 ,  遺伝子 ,  NRF2 ,  欠失 ,  非アルコール性脂肪肝炎 ,  自然発症