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J-GLOBAL ID：201802237764462622   Reference number：18A0975344

Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer’s disease: analysis of Osaka mutation-knockin mice

APP機能の突然変異誘発性消失は劣性家族性Alzheimer病におけるGABA作動性枯渇を引き起こす: 大阪突然変異-ノックインマウスの分析【JST・京大機械翻訳】

Author (21)： Umeda Tomohiro (Department of Translational Neuroscience, Osaka City University Graduate School of Medicine, Osaka, Japan) ,  Umeda Tomohiro (Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi, Japan) ,  Kimura Tetsuya (Department of Aging Neurobiology, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Japan) ,  Yoshida Kayo (Department of Molecular Genetics, Osaka City University Graduate School of Medicine, Osaka, Japan) ,  Takao Keizo (Section of Behavior Patterns, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki, Japan) ,  Takao Keizo (Present address: Life Science Research Center, University of Toyama, Toyama, Japan) ,  Fujita Yuki (Department of Translational Neuroscience, Osaka City University Graduate School of Medicine, Osaka, Japan) ,  Matsuyama Shogo (Biosignal Research Center, Kobe University, Kobe, Japan) ,  Sakai Ayumi (Department of Translational Neuroscience, Osaka City University Graduate School of Medicine, Osaka, Japan) ,  Yamashita Minato (Department of Translational Neuroscience, Osaka City University Graduate School of Medicine, Osaka, Japan) ,  Yamashita Yuki (Department of Translational Neuroscience, Osaka City University Graduate School of Medicine, Osaka, Japan) ,  Ohnishi Kiyouhisa (Department of Translational Neuroscience, Osaka City University Graduate School of Medicine, Osaka, Japan) ,  Suzuki Mamiko (Department of Aging Neurobiology, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Japan) ,  Takuma Hiroshi (Department of Translational Neuroscience, Osaka City University Graduate School of Medicine, Osaka, Japan) ,  Miyakawa Tsuyoshi (Section of Behavior Patterns, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki, Japan) ,  Takashima Akihiko (Department of Aging Neurobiology, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Japan) ,  Morita Takashi (Department of Molecular Genetics, Osaka City University Graduate School of Medicine, Osaka, Japan) ,  Mori Hiroshi (Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi, Japan) ,  Mori Hiroshi (Department of Clinical Neuroscience, Osaka City University Medical School, Osaka, Japan) ,  Tomiyama Takami (Department of Translational Neuroscience, Osaka City University Graduate School of Medicine, Osaka, Japan) ,  Tomiyama Takami (Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi, Japan)
Material： Acta Neuropathologica Communications (Web)
Volume： 5  Issue： 1  Page： 59  Publication year： 2017 
JST Material Number： U7296A  ISSN： 2051-5960  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： The E693Δ (Osaka) mutation in ...

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Thesaurus term： glia cell ,  amyloid beta-protein ,  *mutation ,  *mutagenesis ,  oral administration ,  phosphorylation ,  *Alzheimer disease ,  neuron ,  pathology ,  memory disorder ,  synapse ,  immunohistochemistry ,  wild type ,  aliphatic amine ,  aliphatic carboxylic acid ,  aminocarboxylic acid ,  primary amine
Semi thesaurus term： 同型接合体 , 【Automatic Indexing@JST】

Author keywords (5)： Alzheimer’s disease ,  Recessive mutation ,  Knockin mouse ,  Loss of function ,  GABA

JST classification (5)： Nervous system diseases  (GN03000O) ,  Basic neurology  (GN01020W) ,  Genetic variation  (EC01030Y) ,  Cell physiology in general  (EF02010S) ,  Biological function  (EB03040U)

Substance index (1)： GABA

Reference (32)：

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Terms in the title (9)： APP ,  突然変異誘発性 ,  家族性Alzheimer病 ,  GABA ,  枯渇 ,  大阪 ,  突然変異 ,  ノックインマウス ,  分析