Art

J-GLOBAL ID：201802238216734525   Reference number：18A0418276

Successful Osimertinib Rechallenge with Steroid Therapy after Osimertinib-induced Interstitial Lung Disease

オシメルチニブ誘発性間質性肺疾患後のステロイド療法との成功的オシメルチニブ再チャレンジ

Author (12)： Kiriu Tatsunori (Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan) ,  Tamura Daisuke (Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan) ,  Tachihara Motoko (Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan) ,  Sekiya Reina (Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan) ,  Hazama Daisuke (Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan) ,  Katsurada Masahiro (Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan) ,  Nakata Kyosuke (Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan) ,  Nagano Tatsuya (Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan) ,  Yamamoto Masatsugu (Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan) ,  Kamiryo Hiroshi (Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan) ,  Kobayashi Kazuyuki (Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan) ,  Nishimura Yoshihiro (Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan)
Material： Internal Medicine (Web)  (Intern Med (Web))
Volume： 57  Issue： 1  Page： 91-95(J-STAGE)  Publication year： 2018 
JST Material Number： U0033A  ISSN： 1349-7235  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： *Lung Diseases, Interstitial

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Author keywords (4)： osimertinib ,  interstitial lung disease (ILD) ,  bronchoalveolar lavage (BAL) ,  transbronchial lung biopsy (TBLB)

JST classification (3)： Tumors(=neoplasms)of respiratory system  (GI04000G) ,  Drug therapy(=pharmacotherapy)for tumors  (GE03032C) ,  Clinical application of antitumor(=antineoplastic)drugs  (GW16020L)

Substance index (2)： Osimertinib ,  Prednisolone

Reference (18)：

• 1. Mamesaya N, Kenmotsu H, Katsumata M, et al. Osimertinib-induced interstitial lung disease after treatment with anti PD-1 antibody. Invest New Drugs 35: 105-107, 2017.
• 2. Goss G, Tsai CM, Shepherd FA, et al. Osimertinib for pretreated EGFR Thr790Met-positive advanced non-small-cell lung cancer (AURA2): a multicentre, open-label, single-arm, phase 2 study. Lancet Oncol 17: 1643-1652, 2016.
• 3. Kudoh S, Kato H, Nishiwaki Y, et al. Interstitial lung disease in Japanese patients with lung cancer. A cohort and nested case-control study. Am J Respir Crit Care Med 177: 1348-1357, 2008.
• 4. Shi L, Tang J, Tong L, Liu Z. Risk of interstitial lung disease with gefitinib and erlotinib in advanced non-small cell lung cancer: A systematic review and meta-analysis of clinical trials. Lung Cancer 83: 231-239, 2014.
• 5. Ando M, Okamoto I, Yamamoto N, et al. Predictive factors for interstitial lung disease, antitumor response, and survival in non-small-cell lung cancer patients treated with gefitinib. J Clin Oncol 24: 2549-2556, 2006.

Terms in the title (4)： オシメルチニブ ,  間質性肺疾患 ,  ステロイド療法 ,  成功