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J-GLOBAL ID：201802239005591720   Reference number：18A0966180

DNA methylation regulates discrimination of enhancers from promoters through a H3K4me1-H3K4me3 seesaw mechanism

DNAメチル化はH3K4Me1-H3K4me3シーソー機構を介してプロモータからのエンハンサーの識別を調節する【JST・京大機械翻訳】

Author (20)： Sharifi-Zarchi Ali (Department of Bioinformatics, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran) ,  Sharifi-Zarchi Ali (Computer Science Department, Colorado State University, Fort Collins, USA) ,  Sharifi-Zarchi Ali (Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran) ,  Sharifi-Zarchi Ali (Department of Computer Engineering, Sharif University of Technology, Tehran, Iran) ,  Gerovska Daniela (Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, San Sebastian, Spain) ,  Adachi Kenjiro (Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Muenster, Germany) ,  Totonchi Mehdi (Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran) ,  Pezeshk Hamid (School of Mathematics, Statistics and Computer Science, College of Science, University of Tehran, Tehran, Iran) ,  Pezeshk Hamid (School of Biological Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran) ,  Taft Ryan J. (Illumina Inc., San Diego, USA) ,  Scholer Hans R. (Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Muenster, Germany) ,  Scholer Hans R. (Medical Faculty, University of Muenster, Muenster, Germany) ,  Chitsaz Hamidreza (Computer Science Department, Colorado State University, Fort Collins, USA) ,  Sadeghi Mehdi (School of Biological Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran) ,  Sadeghi Mehdi (National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran) ,  Baharvand Hossein (Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran) ,  Baharvand Hossein (Department of Developmental Biology, University of Science and Culture, Tehran, Iran) ,  Arauzo-Bravo Marcos J. (Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, San Sebastian, Spain) ,  Arauzo-Bravo Marcos J. (Computational Biology and Bioinformatics Group, Max Planck Institute for Molecular Biomedicine, Muenster, Germany) ,  Arauzo-Bravo Marcos J. (IKERBASQUE, Basque Foundation for Science, Bilbao, Spain)
Material： BMC Genomics (Web)
Volume： 18  Issue： 1  Page： 964  Publication year： 2017 
JST Material Number： U7048A  ISSN： 1471-2164  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： DNA methylation at promoters i...

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Thesaurus term： cell division ,  chromatin ,  crosstalk(interaction) ,  genome ,  gene expression ,  *methylation ,  *DNA ,  *promoter(genetics) ,  protein
Semi thesaurus term： エピゲノム ,  ヒストン修飾 ,  CpGアイランド ,  CpG ,  低メチル化 ,  *DNAメチル化 , 【Automatic Indexing@JST】

Author keywords (8)： DNA methylation ,  Histone modifications ,  Promoters ,  Enhancers ,  H3K4me1 ,  H3K4me3 ,  Computational epigenomics ,  Next generation sequencing

JST classification (1)： Gene expression  (EC02040Q)

Reference (98)：

• Genome Res; Disclosing the crosstalk among DNA methylation, transcription factors, and histone marks in human pluripotent cells through discovery of DNA methylation motifs; P-L Luu, HR Schöler, MJ Araúzo-Bravo; 23; 12; 2013; 2013-2029; 10.1101/gr.155960.113; citation_id=CR1
• Nat Genet; Identification of genetic elements that autonomously determine DNA methylation states; F Lienert, C Wirbelauer, I Som, A Dean, F Mohn, D Schübeler; 43; 11; 2011; 1091-1097; 10.1038/ng.946; citation_id=CR2
• J Biol Chem; The chromatin fingerprint of gene enhancer elements; GE Zentner, PC Scacheri; 287; 37; 2012; 30888-30896; 10.1074/jbc.R111.296491; citation_id=CR3
• Cell; Functional and mechanistic diversity of distal transcription enhancers; M Bulger, M Groudine; 144; 3; 2011; 327-339; 10.1016/j.cell.2011.01.024; citation_id=CR4
• Nat Rev Genet; Functions of DNA methylation: islands, start sites, gene bodies and beyond; PA Jones; 13; 7; 2012; 484-492; 10.1038/nrg3230; citation_id=CR5

Terms in the title (5)： DNAメチル化 ,  H3K4me3 ,  プロモータ ,  識別 ,  調節