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J-GLOBAL ID：201802240258503988   Reference number：18A0279371

Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial

dupilumabと付随する局所コルチコステロイド(LIBERTY AD CHRONOS)を用いた中等度から重度のアトピー性皮膚炎の長期管理:1年間の無作為化,二重盲検,プラセボ対照,第3相試験【Powered by NICT】

Author (31)： Blauvelt Andrew (Oregon Medical Research Center, Portland, OR, USA) ,  de Bruin-Weller Marjolein (University Medical Center Utrecht, Utrecht, Netherlands) ,  Gooderham Melinda (SKiN Centre for Dermatology, Queen’s University, and Probity Medical Research, Peterborough, ON, Canada) ,  Cather Jennifer C (Modern Dermatology and Modern Research Associates, and Probity Medical Research, Dallas, TX, USA) ,  Weisman Jamie (Advanced Medical Research, PC, Atlanta, GA, USA) ,  Pariser David (Eastern Virginia Medical School and Virginia Clinical Research Inc, Norfolk, VA, USA) ,  Simpson Eric L (Oregon Health and Science University, Portland, OR, USA) ,  Papp Kim A (K Papp Clinical Research and Probity Medical Research, Waterloo, ON, Canada) ,  Hong H Chih-Ho (Department of Dermatology and Skin Science, University of British Columbia, and Probity Medical Research, Surrey, BC, Canada) ,  Rubel Diana (Australian National University, Canberra, and Probity Medical Research, Phillip, ACT, Australia) ,  Foley Peter (The University of Melbourne, Parkville, Skin & Cancer Foundation Inc, Carlton, and Probity Medical Research, Carlton, VIC, Australia) ,  Prens Errol (Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands) ,  Griffiths Christopher E M (The Dermatology Centre, Salford Royal Hospital, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK) ,  Etoh Takafumi (Tokyo Teishin Postal Services Agency Hospital, Tokyo, Japan) ,  Pinto Pedro Herranz (Department of Dermatology, La Paz University Hospital, Madrid, Spain) ,  Pujol Ramon M (Department of Dermatology, Hospital del Mar, Barcelona, Spain) ,  Szepietowski Jacek C (Department of Dermatology, Venereology and Allergology, Wroclaw, Poland) ,  Ettler Karel (Dermatology and Venereology, Hradec Kralove, Czech Republic) ,  Kemeny Lajos (Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary) ,  Zhu Xiaoping (Regeneron Pharmaceuticals Inc, Basking Ridge, NJ, USA) ,  Akinlade Bolanle (Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA) ,  Hultsch Thomas (Sanofi, Cambridge, MA, USA) ,  Mastey Vera (Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA) ,  Gadkari Abhijit (Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA) ,  Eckert Laurent (Sanofi, Chilly-Mazarin, France) ,  Amin Nikhil (Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA) ,  Graham Neil M H (Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA) ,  Pirozzi Gianluca (Sanofi, Bridgewater, NJ, USA) ,  Stahl Neil (Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA) ,  Yancopoulos George D (Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA) ,  Shumel Brad (Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA)
Material： Lancet
Volume： 389  Issue： 10086  Page： 2287-2303  Publication year： 2017 
JST Material Number： B0673A  ISSN： 0140-6736  CODEN： LANCA  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Dupilumab (an anti-interleukin...

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Thesaurus term： Europe ,  *placebo ,  United States of America ,  patient ,  asthma ,  *long term management ,  *atopic dermatitis ,  interaction ,  monoclonal antibody ,  therapy ,  *phase 3 study ,  hospital ,  safety ,  *double blind test
Semi thesaurus term： *ステロイド外用薬 , 【Automatic Indexing@JST】

JST classification (2)： Immunologic diseases,allergic diseases in general.  (GD04010C) ,  Treatment for immunologic diseases,allergic diseases.  (GD04030Y)

Terms in the title (8)： 局所コルチコステロイド ,  AD ,  アトピー性皮膚炎 ,  長期 ,  二重盲検 ,  プラセボ ,  対照 ,  第3相試験