Art

J-GLOBAL ID：201802240493153180   Reference number：18A0153795

CNB-001, a synthetic pyrazole derivative of curcumin, suppresses lipopolysaccharide-induced nitric oxide production through the inhibition of NF-κB and p38 MAPK pathways in microglia

クルクミンの合成ピラゾール誘導体CNB001はミクログリアにおけるNF-κBとp38MAPK経路の阻害を介してリポ多糖類誘発一酸化窒素産生を抑制する【Powered by NICT】

Author (2)： Akaishi Tatsuhiro (Laboratory of Pharmacology, Faculty of Pharmacy and Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo 202-8585, Japan) ,  Abe Kazuho (Laboratory of Pharmacology, Faculty of Pharmacy and Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo 202-8585, Japan)
Material： European Journal of Pharmacology  (Eur J Pharmacol)
Volume： 819  Page： 190-197  Publication year： 2018 
JST Material Number： B0841A  ISSN： 0014-2999  CODEN： EJPHAZ  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： CNB-001, a pyrazole derivative...

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Thesaurus term： phosphorylation ,  nitric oxide synthase ,  anti-inflammatory action ,  *nitrogen monoxide ,  *NF-kappaB ,  Alzheimer disease ,  *p38 MAP kinase ,  ERK ,  *lipopolysaccharide ,  primary culture ,  pathogenesis ,  *microglia ,  diene ,  phenolic compound ,  phenol ether ,  enone ,  diketone
Semi thesaurus term： *P38 ,  神経保護 , 【Automatic Indexing@JST】

Author keywords (6)： Microglia ,  CNB-001 ,  Nitric oxide (NO) ,  Inducible NO synthase (iNOS) ,  Nuclear factor-κB (NF-κB) ,  Mitogen-activated protein kinase (MAPK)

JST classification (4)： Basic research of anti-inflammatory drugs  (GW15010T) ,  Basic research of addictive analgesics and narcotics  (GW03080Z) ,  Receptors on cell membrane  (EF04030C) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (1)： Curcumin

Terms in the title (8)： クルクミン ,  ピラゾール誘導体 ,  ミクログリア ,  NF-κB ,  阻害 ,  リポ多糖類 ,  誘発 ,  一酸化窒素