Art

J-GLOBAL ID：201802240747236092   Reference number：18A1281462

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

PARP捕捉損傷の供給源はゲノム中のリボヌクレオチドであることがCRISPRを用いたスクリーニングにより明らかになった

Author (27)： ZIMMERMANN Michal (Mount Sinai Hospital, Ontario, CAN) ,  MCEWAN Andrea (Mount Sinai Hospital, Ontario, CAN) ,  DUROCHER Daniel (Mount Sinai Hospital, Ontario, CAN) ,  MURINA Olga (Univ. Edinburgh, Edinburgh, GBR) ,  REIJNS Martin A. M. (Univ. Edinburgh, Edinburgh, GBR) ,  CHALLIS Rachel (Univ. Edinburgh, Edinburgh, GBR) ,  TARNAUSKAITE Zygimante (Univ. Edinburgh, Edinburgh, GBR) ,  FLUTEAU Adeline (Univ. Edinburgh, Edinburgh, GBR) ,  JACKSON Andrew P. (Univ. Edinburgh, Edinburgh, GBR) ,  AGATHANGGELOU Angelo (Univ. Birmingham, Birmingham, GBR) ,  STANKOVIC Tatjana (Univ. Birmingham, Birmingham, GBR) ,  MUIR Morwenna (Univ. Edinburgh, Edinburgh, GBR) ,  BRUNTON Valerie G. (Univ. Edinburgh, Edinburgh, GBR) ,  AREGGER Michael (Univ. Toronto, Ontario, CAN) ,  CHANDRASHEKHAR Megha (Univ. Toronto, Ontario, CAN) ,  MOFFAT Jason (Univ. Toronto, Ontario, CAN) ,  YUAN Wei (Inst. of Cancer Res., London, GBR) ,  CLARKE Matthew (Inst. of Cancer Res., London, GBR) ,  LAMBROS Maryou B. (Inst. of Cancer Res., London, GBR) ,  DE BONO Johann (Inst. of Cancer Res., London, GBR) ,  PANEESHA Shankara (Heartlands Hospital, Birmingham, GBR) ,  MOSS Paul (Univ. Birmingham, Birmingham, GBR) ,  DUROCHER Daniel (Univ. Toronto, Ontario, CAN) ,  ANGERS Stephane (Univ. Toronto, Ontario, CAN) ,  MOFFAT Jason (Canadian Inst. for Advanced Res., Ontario, CAN) ,  HART Traver (Univ. Texas MD Anderson Cancer Center, TX, USA) ,  DE BONO Johann (Royal Marsden NHS Foundation Trust, London, GBR)
Material： Nature (London)  (Nature (Lond))
Volume： 559  Issue： 7713  Page： 285-289  Publication year： Jul. 12, 2018 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *capture ,  DNA Replication ,  *genome ,  prostatic tumor ,  excision repair ,  sensitivity ,  cytotoxicity ,  *ribonucleotide ,  *screening (inspection) ,  Proteins ,  DNA ,  DNA lesion ,  therapy ,  Genetic Variation
Semi thesaurus term： variation(biology) ,  阻害剤 , 【Automatic Indexing@JST】

JST classification (1)： Molecular genetics in general  (EC02010J)

Terms in the title (8)： PARP ,  捕捉 ,  損傷 ,  供給源 ,  ゲノム ,  リボヌクレオチド ,  CRISPR ,  スクリーニング