Art

J-GLOBAL ID：201802241075090430   Reference number：18A1226958

Adiponectin deficiency-induced diabetes increases TNFα and FFA via downregulation of PPARα

アディポネクチン欠損誘発糖尿病はPPARαのダウンレギュレーションを介してTNFαとFFAを増加する

Author (9)： HASHIMOTO Haruo (Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan) ,  YAMAMOTO Masafumi (Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan) ,  SUGIURA Emika (Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan) ,  ABE Hayato (Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan) ,  KAGAWA Takahiro (Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan) ,  GOTO Motohito (Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan) ,  TAKAHASHI Ri-ichi (Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan) ,  AKIMOTO Toshio (Division of Laboratory Animal Science, Nippon Medical School, 115 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan) ,  SUEMIZU Hiroshi (Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan)
Material： Journal of Veterinary Medical Science (Web)
Volume： 80  Issue： 4  Page： 662-666(J-STAGE)  Publication year： 2018 
JST Material Number： U1094A  ISSN： 1347-7439  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *PPAR alpha ,...
Semi thesaurus term： abnormal glucose tolerance

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Author keywords (3)： adiponectin ,  diabetes ,  PPARα

JST classification (2)： Metabolism and nutrition of sugar(=glucide)  (EJ02035H) ,  Basic medicine on endocrine system  (GL01020Q)

Reference (18)：

• 1. Combs, T. P., Berg, A. H., Rajala, M. W., Klebanov, S., Iyengar, P., Jimenez-Chillaron, J. C., Patti, M. E., Klein, S. L., Weinstein, R. S. and Scherer, P. E. 2003. Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes 52: 268-276.
• 2. Fasshauer, M., Klein, J., Neumann, S., Eszlinger, M. and Paschke, R. 2002. Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun. 290: 1084-1089.
• 3. Fujita, K., Maeda, N., Sonoda, M., Ohashi, K., Hibuse, T., Nishizawa, H., Nishida, M., Hiuge, A., Kurata, A., Kihara, S., Shimomura, I. and Funahashi, T. 2008. Adiponectin protects against angiotensin II-induced cardiac fibrosis through activation of PPAR-alpha. Arterioscler. Thromb. Vasc. Biol. 28: 863-870.
• 4. Hara, K., Boutin, P., Mori, Y., Tobe, K., Dina, C., Yasuda, K., Yamauchi, T., Otabe, S., Okada, T., Eto, K., Kadowaki, H., Hagura, R., Akanuma, Y., Yazaki, Y., Nagai, R., Taniyama, M., Matsubara, K., Yoda, M., Nakano, Y., Tomita, M., Kimura, S., Ito, C., Froguel, P. and Kadowaki, T. 2002. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 51: 536-540.
• 5. Hashimoto, H., Kamisako, T., Kagawa, T., Haraguchi, S., Yagoto, M., Takahashi, R., Kawai, K. and Suemizu, H. 2015. Expression of pancreatic and duodenal homeobox1 (PDX1) protein in the interior and exterior regions of the intestine, revealed by development and analysis of Pdx1 knockout mice. Lab. Anim. Res. 31: 93-98.

Terms in the title (7)： アディポネクチン ,  欠損 ,  誘発 ,  糖尿病 ,  PPARα ,  ダウンレギュレーション ,  TNFα