Art

J-GLOBAL ID：201802241563845843   Reference number：18A2080432

Flexibility of small molecular CD4 mimics as HIV entry inhibitors

HIV侵入阻害剤としての小分子CD4模倣体の柔軟性【JST・京大機械翻訳】

Author (11)： Kobayakawa Takuya (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan) ,  Ohashi Nami (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan) ,  Hirota Yuki (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan) ,  Takahashi Kohei (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan) ,  Yamada Yuko (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan) ,  Narumi Tetsuo (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan) ,  Yoshimura Kazuhisa (AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan) ,  Yoshimura Kazuhisa (Center for AIDS Research, Kumamoto University, Kumamoto 860-0811, Japan) ,  Matsushita Shuzo (Center for AIDS Research, Kumamoto University, Kumamoto 860-0811, Japan) ,  Harada Shigeyoshi (AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan) ,  Tamamura Hirokazu (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 26  Issue： 21  Page： 5664-5671  Publication year： 2018 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： CD4 mimics such as YIR-821 and...

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Thesaurus term： *CD4 antigen ,  HIV ,  *small molecule ,  interaction ,  HIV1 ,  *flexibility ,  linker ,  benzene ring ,  HIV Envelope Protein gp120 ,  Anti-HIV activity ,  microorganism ,  animal virus ,  amino acid ,  aliphatic amine ,  aliphatic carboxylic acid ,  nitrogen heterocyclic compound ,  polynuclear aromatic compound
Semi thesaurus term： *阻害剤 ,  抗HIV活性 , 【Automatic Indexing@JST】

Author keywords (5)： CD4 mimic ,  Oxalamide linker ,  Indole ,  Entry inhibitor ,  Anti-HIV

JST classification (2)： Basic research of antiviral drugs  (GW17040O) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (4)： Glycine ,  Indole ,  Guanidine ,  Piperidine

Terms in the title (5)： HIV ,  侵入阻害剤 ,  小分子 ,  CD4 ,  模倣