Art

J-GLOBAL ID：201802242145309463   Reference number：18A1188690

The induced RNA-binding protein, HuR, targets 3′-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis

誘導RNA結合蛋白質HuRはIL-6 mRNAの3′-UTR領域を標的とし,歯周炎におけるその安定化を増強する【JST・京大機械翻訳】

Author (14)： Ouhara K. (Department of Periodontal Medicine, Graduate School of Biomedical and Sciences, Hiroshima University, Hiroshima, Japan) ,  Munenaga S. (Department of Periodontal Medicine, Graduate School of Biomedical and Sciences, Hiroshima University, Hiroshima, Japan) ,  Kajiya M. (Department of Periodontal Medicine, Graduate School of Biomedical and Sciences, Hiroshima University, Hiroshima, Japan) ,  Takeda K. (Department of Periodontal Medicine, Graduate School of Biomedical and Sciences, Hiroshima University, Hiroshima, Japan) ,  Matsuda S. (Department of Periodontal Medicine, Graduate School of Biomedical and Sciences, Hiroshima University, Hiroshima, Japan) ,  Sato Y. (Department of Periodontal Medicine, Graduate School of Biomedical and Sciences, Hiroshima University, Hiroshima, Japan) ,  Hamamoto Y. (Department of Periodontal Medicine, Graduate School of Biomedical and Sciences, Hiroshima University, Hiroshima, Japan) ,  Iwata T. (Department of Periodontal Medicine, Graduate School of Biomedical and Sciences, Hiroshima University, Hiroshima, Japan) ,  Yamasaki S. (Kurume University Medical Center, Fukuoka, Japan) ,  Akutagawa K. (Department of Periodontal Medicine, Graduate School of Biomedical and Sciences, Hiroshima University, Hiroshima, Japan) ,  Mizuno N. (Department of Periodontal Medicine, Graduate School of Biomedical and Sciences, Hiroshima University, Hiroshima, Japan) ,  Fujita T. (Department of Periodontal Medicine, Graduate School of Biomedical and Sciences, Hiroshima University, Hiroshima, Japan) ,  Sugiyama E. (Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan) ,  Kurihara H. (Department of Periodontal Medicine, Graduate School of Biomedical and Sciences, Hiroshima University, Hiroshima, Japan)
Material： Clinical and Experimental Immunology  (Clin Exp Immunol)
Volume： 192  Issue： 3  Page： 325-336  Publication year： 2018 
JST Material Number： E0159B  ISSN： 0009-9104  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： RNA-binding proteins (RBPs) re...

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Thesaurus term： *mRNA ,  lipopolysaccharide ,  in vivo experiment ,  Down-Regulation ,  human ,  siRNA ,  epithelium ,  in vitro experiment ,  Diabetes Mellitus ,  TNF alpha ,  *interleukin 6 ,  inflammatory cytokine ,  immunohistochemistry ,  mRNA expression ,  *HuR ,  membrane and film ,  histomembrane

Author keywords (5)： HuR ,  IL-6 ,  periodontitis ,  Porphyromonas gingivalis ,  RNA-binding protein

JST classification (2)： Gene expression  (EC02040Q) ,  Immunological reaction in general  (ED03010T)

Terms in the title (10)： 誘導 ,  RNA結合蛋白質 ,  HuR ,  IL-6 ,  mRNA ,  UTR ,  標的 ,  歯周炎 ,  安定化 ,  増強