Art

J-GLOBAL ID：201802242606279471   Reference number：18A1241739

Variation in CYP2A6 Activity and Personalized Medicine

CYP2A6活性と個別化医療における変動【JST・京大機械翻訳】

Author (5)： Tanner Julie-Anne (Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON M5T 1R8, Canada) ,  Tanner Julie-Anne (Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada) ,  Tyndale Rachel F. (Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON M5T 1R8, Canada) ,  Tyndale Rachel F. (Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada) ,  Tyndale Rachel F. (Department of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada)
Material： Journal of Personalized Medicine (Web)
Volume： 7  Issue： 4  Page： 18  Publication year： 2017 
JST Material Number： U7226A  ISSN： 2075-4426  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： The cytochrome P450 2A6 (CYP2A...

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Thesaurus term： lung tumor ,  tobacco (favorite) ,  enzyme activity ,  smoking (tobacco) ,  Heredity ,  drug metabolism ,  *Individualized Medicine ,  enzyme ,  gene ,  coenzyme ,  cytochrome P450 ,  Genetic Variation ,  lactam ,  central nervous system stimulant ,  urea compound ,  nitrogen heterocyclic compound ,  drug ,  tobacco alkaloid
Semi thesaurus term： genetic variation , 【Automatic Indexing@JST】

Author keywords (10)： pharmacogenetics ,  pharmacogenomics ,  drug metabolism ,  CYP2A6 ,  smoking ,  nicotine ,  genetic variation ,  SNP ,  inhibitor ,  inducer

JST classification (2)： Molecular genetics in general  (EC02010J) ,  Basic biopharmacy  (GY01021U)

Substance index (3)： Caffeine ,  Cotinine ,  Nicotine

Reference (186)：

• Koskela, S.; Hakkola, J.; Hukkanen, J.; Pelkonen, O.; Sorri, M.; Saranen, A.; Anttila, S.; Fernandez-Salguero, P.; Gonzalez, F.; Raunio, H. Expression of CYP2A genes in human liver and extrahepatic tissues. Biochem. Pharmacol. 1999, 57, 1407-1413.
• McDonagh, E.M.; Wassenaar, C.; David, S.P.; Tyndale, R.F.; Altman, R.B.; Whirl-Carrillo, M.; Klein, T.E. PharmGKB summary: Very important pharmacogene information for cytochrome P-450, family 2, subfamily A, polypeptide 6. Pharmacogenet. Genom. 2012, 22, 695-708.
• Loukola, A.; Buchwald, J.; Gupta, R.; Palviainen, T.; Hallfors, J.; Tikkanen, E.; Korhonen, T.; Ollikainen, M.; Sarin, A.P.; Ripatti, S.; et al. A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism. PLoS Genet. 2015, 11, e1005498.
• Tanner, J.A.; Prasad, B.; Claw, K.G.; Stapleton, P.; Chaudhry, A.; Schuetz, E.G.; Thummel, K.E.; Tyndale, R.F. Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors. J. Pharmacol. Exp. Ther. 2017, 360, 129-139.
• Hukkanen, J.; Jacob, P., III; Benowitz, N.L. Effect of grapefruit juice on cytochrome P450 2A6 and nicotine renal clearance. Clin. Pharmacol. Ther. 2006, 80, 522-530.

Terms in the title (3)： CYP2A6 ,  活性 ,  個別化医療