Art

J-GLOBAL ID：201802243041419254   Reference number：18A0929050

Functional characterization of recombinant snake venom rhodocytin: rhodocytin mutant blocks CLEC-2/podoplanin-dependent platelet aggregation and lung metastasis

組換えヘビ毒ロドシスチンの機能的特性化 ロダクチン変異体はCLEC-2/ポドプラニン依存性血小板凝集と肺転移を阻止する【JST・京大機械翻訳】

Author (10)： Sasaki T. (Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, Kofu, Japan) ,  Shirai T. (Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, Kofu, Japan) ,  Tsukiji N. (Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, Kofu, Japan) ,  Otake S. ,  Tamura S. (Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Ichikawa J. (Department of Orthopedic Surgery, Faculty of Medicine, University of Yamanashi, Kofu, Japan) ,  Osada M. (School of Medical Technology, Gunma Paz University, Takasaki, Japan) ,  Satoh K. (Division of Laboratory Medicine, University of Yamanashi Hospital, Kofu, Japan) ,  Ozaki Y. (Fuefuki Central Hospital, Fuefuki, Japan) ,  Suzuki-Inoue K. (Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, Kofu, Japan)
Material： Journal of Thrombosis and Haemostasis  (J Thromb Haemost)
Volume： 16  Issue： 5  Page： 960-972  Publication year： 2018 
JST Material Number： W1621A  ISSN： 1538-7933  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Essentials We generated recomb...

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Thesaurus term： therapy ,  wild type ,  *characterization ,  tumor ,  multimer ,  disulfide bond ,  subunit ,  mutagenesis ,  *platelet aggregation ,  *thrombocyte ,  tumor cell ,  metastasis ,  flow cytometry ,  interaction
Semi thesaurus term： *CLEC2 , 【Automatic Indexing@JST】

Author keywords (5)： CLEC-2 ,  metastasis ,  platelet aggregation ,  rhodocytin ,  tumor

JST classification (1)： Enzyme in general  (EB09010D)

Terms in the title (10)： 組換え ,  ヘビ毒 ,  特性化 ,  変異体 ,  CLEC-2 ,  ポドプラニン ,  依存性 ,  血小板凝集 ,  肺転移 ,  阻止