Art

J-GLOBAL ID：201802243184424960   Reference number：18A1005263

Enhanced IFN-α production is associated with increased TLR7 retention in the lysosomes of palasmacytoid dendritic cells in systemic lupus erythematosus

増強されたIFN-α産生は全身性エリテマトーデスにおけるPalasmacytoid樹状細胞のリソソームにおけるTLR7保持の増加と関連する【JST・京大機械翻訳】

Author (7)： Murayama Goh (Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan) ,  Murayama Goh (Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan) ,  Furusawa Nanako (Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan) ,  Chiba Asako (Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan) ,  Yamaji Ken (Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan) ,  Tamura Naoto (Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan) ,  Miyake Sachiko (Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan)
Material： Arthritis Research & Therapy (Web)
Volume： 19  Issue： 1  Page： 234  Publication year： 2017 
JST Material Number： U7412A  ISSN： 1478-6362  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Background Interferon-α (IFN-α...

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Thesaurus term： flow cytometry ,  interferon alpha ,  pathogenesis ,  patient ,  Toll like receptor ,  *dendritic cell ,  *systemic lupus erythematosus ,  in vitro experiment ,  serum ,  endosome ,  *lysosome
Semi thesaurus term： アゴニスト ,  Toll様受容体9 ,  形質細胞様樹状細胞 ,  *Toll様受容体7 , 【Automatic Indexing@JST】

Author keywords (4)： Systemic lupus erythematosus ,  Toll-like receptor ,  Interferon-α ,  Plasmacytoid dendritic cells

JST classification (2)： Immunological reaction in general  (ED03010T) ,  Infectious immunity  (ED03030P)

Reference (62)：

• J Immunol; Type I Interferon in the pathogenesis of Lupus; MK Crow; 192; 2014; 5459-68; 10.4049/jimmunol.1002795; CR1;
• Rheumatology; Type I interferon blockade in systemic lupus erythematosus: where do we stand?; BR Lauwerys, J Ducreux, FA Houssiau; 53; 2014; 1369-76; 10.1093/rheumatology/ket403; CR2;
• Semin Immunol; The type I interferon system in the development of lupus; L Rönnblom, GV Alm, ML Eloranta; 23; 2011; 113-21; 10.1016/j.smim.2011.01.009; CR3;
• J Immunol; IFN-α induces early lethal lupus in preautoimmune (New Zealand Black x New Zealand White) F1 but not in BALB/c mice; A Mathian, A Weinberg, M Gallegos, J Banchereau, S Koutouzov; 174; 2005; 2499-506; 10.4049/jimmunol.174.5.2499; CR4;
• J Exp Med; Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice; ML Santiago-Raber, R Baccala, KM Haraldsson, D Choubey, TA Stewart, DH Kono, AN Theofilopoulos; 197; 2003; 777-88; 10.1084/jem.20021996; CR5;

Terms in the title (6)： 増強 ,  IFN ,  全身性エリテマトーデス ,  樹状細胞 ,  リソソーム ,  TLR7