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J-GLOBAL ID：201802245525456340   Reference number：18A0081682

Co-treatment with a C1B5 peptide of protein kinase Cγ and a low dose of gemcitabine strongly attenuated pancreatic cancer growth in mice through T cell activation

蛋白質キナーゼCγのC1B5ペプチドとの併用療法とT細胞活性化を介してマウスにおけるゲムシタビン強く減弱膵臓癌成長の低用量【Powered by NICT】

Author (10)： Ishiguro Susumu (Departments of Anatomy & Physiology, Kansas State University College of Veterinary Medicine, Manhattan, KS, 66506, USA) ,  Kawabata Atsushi (Departments of Anatomy & Physiology, Kansas State University College of Veterinary Medicine, Manhattan, KS, 66506, USA) ,  Zulbaran-Rojas Alejandro (Departments of Anatomy & Physiology, Kansas State University College of Veterinary Medicine, Manhattan, KS, 66506, USA) ,  Monson Kelsey (Departments of Anatomy & Physiology, Kansas State University College of Veterinary Medicine, Manhattan, KS, 66506, USA) ,  Uppalapati Deepthi (Departments of Anatomy & Physiology, Kansas State University College of Veterinary Medicine, Manhattan, KS, 66506, USA) ,  Ohta Naomi (Departments of Anatomy & Physiology, Kansas State University College of Veterinary Medicine, Manhattan, KS, 66506, USA) ,  Inui Makoto (Departments of Pharmacology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan) ,  Pappas Charalampos G. (Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, Ioannina 45110, Greece) ,  Tzakos Andreas G. (Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, Ioannina 45110, Greece) ,  Tamura Masaaki (Departments of Anatomy & Physiology, Kansas State University College of Veterinary Medicine, Manhattan, KS, 66506, USA)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 495  Issue： 1  Page： 962-968  Publication year： 2018 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Although gemcitabine is an eff...

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Thesaurus term： coprocessing ,  *combination therapy ,  drug therapy ,  Apoptosis ,  antitumor action ,  *T cell ,  mRNA ,  human ,  culture (biology) ,  *peptide ,  *pancreatic tumor ,  therapeutic planning ,  granzyme B ,  *low dosage ,  halogeno sugar ,  deoxyribonucleoside

Author keywords (6)： C1B domain peptides ,  C1B5 peptide ,  Protein kinase Cγ (PKCγ) ,  Pancreatic cancer ,  T cell activation ,  Apoptosis

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Substance index (1)： Gemcitabine

Terms in the title (10)： 蛋白質キナーゼCγ ,  ペプチド ,  併用療法 ,  T細胞活性化 ,  マウス ,  ゲムシタビン ,  減弱 ,  膵臓癌 ,  成長 ,  低用量