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J-GLOBAL ID：201802245589581497   Reference number：18A0124785

Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons

PC12細胞およびラット小脳か粒ニューロンにおける1-メチル-4-フェニルピリジニウムイオン誘起神経毒性における8 ニトロ cGMP形成を介して一酸化窒素/活性酸素種シグナル伝達の関与【Powered by NICT】

Author (12)： Masuda Kumiko (Department of Biological Science, Graduate School of Science, Osaka Prefecture University, Osaka, Japan) ,  Masuda Kumiko (Project Management Department, SHIONOGI & CO., LTD., Osaka, Japan) ,  Tsutsuki Hiroyasu (Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Kasamatsu Shingo (Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Ida Tomoaki (Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Takata Tsuyoshi (Department of Pharmacology, Showa Pharmaceutical University, Machida, Tokyo, Japan) ,  Sugiura Kikuya (Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka, Japan) ,  Nishida Motohiro (Division of Cardiocirculatory Signaling, National Institute for Physiological Sciences (Okazaki Institute for Integrative Bioscience), National Institutes of Natural Sciences, Aichi, Japan) ,  Watanabe Yasuo (Department of Pharmacology, Showa Pharmaceutical University, Machida, Tokyo, Japan) ,  Sawa Tomohiro (Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan) ,  Akaike Takaaki (Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Ihara Hideshi (Department of Biological Science, Graduate School of Science, Osaka Prefecture University, Osaka, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 495  Issue： 3  Page： 2165-2170  Publication year： 2018 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： To investigate the role of nit...

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Thesaurus term： ERK ,  *cerebellum ,  phosphorylation ,  Parkinson's disease ,  oxidation-reduction reaction ,  *nitrogen monoxide ,  Ras protein ,  *PC12 cell ,  *neuron ,  nitric oxide synthase ,  *neurotoxicity
Semi thesaurus term： 阻害剤 ,  ERKキナーゼ ,  一酸化窒素シンターゼI ,  *小脳顆粒細胞 , 【Automatic Indexing@JST】

Author keywords (6)： nNOS ,  NO/ROS redox signaling ,  8-nitro-cGMP ,  H-Ras/ERK signaling ,  MPP⁺ ,  Neurotoxicity

JST classification (2)： Function of cell components  (EF03060C) ,  Nervous system diseases  (GN03000O)

Terms in the title (9)： PC12細胞 ,  ラット ,  小脳か粒ニューロン ,  誘起 ,  神経毒性 ,  cGMP ,  一酸化窒素 ,  活性酸素種 ,  シグナル伝達