Art

J-GLOBAL ID：201802245631152548   Reference number：18A0551809

Isogloiosiphone B, a novel acetal, and hydrophobic compounds as β-glucuronidase inhibitors derived from the red alga Neodilsea yendoana

紅藻アカバNeodilsea yendoana由来のβ-グルクロニダーゼ阻害剤である新規のアセタールおよび疎水性化合物であるイソグロイオシフォンB

Author (2)： ZHANG Duo (Hokkaido Univ., Hakodate, JPN) ,  KURIHARA Hideyuki (Hokkaido Univ., Hakodate, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 82  Issue： 1  Page： 46-48  Publication year： Jan. 2018 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 短報  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： Rhodophyta ,...
Semi thesaurus term： *Neodilsea yendoana ,...

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JST classification (3)： Aliphatic ketones  (CF03190Q) ,  Biosubstance in general  (EB02010G) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (1)： Isogloiosiphone B

Reference (23)：

• Khan KM, Saad SM, Shaikh NN, et al. Synthesis and beta-glucuronidase inhibitory activity of 2-arylquinazolin-4(3H)-ones. Bioorg Med Chem. 2014;22:3449-3454.
• Oleson L, Court MH. Effect of the β-glucuronidase inhibitor saccharolactone on glucuronidation by human tissue microsomes and recombinant UDP-glucuronosyltransferases (UGTs). J Pharm Pharmacol. 2008;60(9):1175-1182.
• Boyer MJ, Tannock IF. Lysosomes, lysosomal enzymes, and cancer. Adv Cancer Res. 1992;60:269-291.
• Marsh CA, Alexander F, Levvy GA. Glucuronide decomposition in the digestive tract. Nature. 1952;170:163-164.
• Swank RT, Pfister K, Miller D, et al. The egasyn gene affects the processing of oligosaccharides of lysosomal beta-glucuronidase in liver. Biochem J. 1986;240:445-454.

Terms in the title (5)： 紅藻 ,  β-グルクロニダーゼ ,  阻害剤 ,  アセタール ,  疎水性化合物