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J-GLOBAL ID：201802246096646064   Reference number：18A1785520

Functional Modulation of Na_v1.2 Voltage-Gated Sodium Channels Induced by Escitalopram

エスシタロプラムにより誘発されるNa_v1.2電位依存性ナトリウムチャンネルの機能的調節

Author (2)： Nakatani Yoshihiko (Department of Pharmacotherapeutics, School of Pharmacy, International University of Health and Welfare) ,  Amano Taku (Department of Pharmacotherapeutics, School of Pharmacy, International University of Health and Welfare)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 41  Issue： 9  Page： 1471-1474(J-STAGE)  Publication year： 2018 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *sodium channel ,...
Semi thesaurus term： *NAV1.2 Voltage-Gated Sodium Channel ,...

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Author keywords (6)： escitalopram ,  Na_v1.2 voltage-gated sodium channels (VGSCs) ,  HEK293 ,  escitalopram ,  Na_v1.2 voltage-gated sodium channels (VGSCs) ,  HEK293

JST classification (2)： Basic research of psychotropic drugs  (GW03100Y) ,  Transport of cell membrane  (EF04020R)

Substance index (1)： Escitalopram

Reference (18)：

• 1) Chen F, Larsen MB, Sánchez C, Wiborg O. The S-enantiomer of R,S-citalopram, increases inhibitor binding to the human serotonin transporter by an allosteric mechanism. Comparison with other serotonin transporter inhibitors. Eur. Neuropsychopharmacol., 15, 193-198 (2005).
• 2) Owens MJ, Knight DL, Nemeroff CB. Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine. Biol. Psychiatry, 50, 345-350 (2001).
• 3) Hill T, Coupland C, Morriss R, Arthur A, Moore M, Hippisley-Cox J. Antidepressant use and risk of epilepsy and seizures in people aged 20 to 64 years: cohort study using a primary care database. BMC Psychiatry, 15, 315 (2015).
• 4) Citrome L. Vortioxetine for major depressive disorder: An indirect comparison with duloxetine, escitalopram, levomilnacipran, sertraline, venlafaxine, and vilazodone, using number needed to treat, number needed to harm, and likelihood to be helped or harmed. J. Affect. Disord., 196, 225-233 (2016).
• 5) Bruccoleri RE, Burns MM. A literature review of the use of sodium bicarbonate for the treatment of QRS widening. J. Med. Toxicol., 12, 121-129 (2016).

Terms in the title (4)： エスシタロプラム ,  誘発 ,  電位依存性ナトリウムチャンネル ,  調節