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J-GLOBAL ID：201802247820825774   Reference number：18A1913655

Yokukansan Ameliorates Hippocampus-Dependent Learning Impairment in Senescence-Accelerated Mouse

抑肝散は老化促進マウスにおける海馬依存性学習障害を改善する

Author (9)： Azuma Kagaku (Department of Anatomy, School of Medicine, University of Occupational and Environmental Health) ,  Toyama Tatsuya (Department of Pediatric Dentistry, Asahi University School of Dentistry) ,  Katano Masahisa (Department of Pediatric Dentistry, Asahi University School of Dentistry) ,  Kajimoto Kyoko (Department of Pediatric Dentistry, Asahi University School of Dentistry) ,  Hayashi Sakurako (Department of Pediatric Dentistry, Asahi University School of Dentistry) ,  Suzuki Ayumi (Department of Pediatric Dentistry, Asahi University School of Dentistry) ,  Tsugane Hiroko (Department of Pediatric Dentistry, Asahi University School of Dentistry) ,  Iinuma Mitsuo (Department of Pediatric Dentistry, Asahi University School of Dentistry) ,  Kubo Kin-ya (Faculty of Human Life and Environmental Science, Nagoya Women’s Univrsity)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 41  Issue： 10  Page： 1593-1599(J-STAGE)  Publication year： 2018 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： mouse(animal) ,...
Semi thesaurus term： synapse plasticity ,...

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Author keywords (12)： yokukansan ,  hippocampus ,  learning ability ,  myelin sheath ,  neurogenesis ,  synapse ,  yokukansan ,  hippocampus ,  learning ability ,  myelin sheath ,  neurogenesis ,  synapse

JST classification (4)： Basic research of pharmacology of crude drugs  (GX06020J) ,  Central nervous system  (EJ12030F) ,  Basic neurology  (GN01020W) ,  Basic research of other drugs acting on central nervous system  (GW03120U)

Reference (46)：

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• 2) Vivar C. Adult hippocampal neurogenesis, aging and neurodegenerative diseases: Possible strategies to prevent cognitive impairment. Curr. Top. Med. Chem., 15, 2175-2192 (2015).
• 3) Lazarov O, Hollands C. Hippocampal neurogenesis: Learning to remember. Prog. Neurobiol., 138-140, 1-18 (2016).
• 4) Mu Y, Gage FH. Adult hippocampal neurogenesis and its role in Alzheimer’s disease. Mol. Neurodegener., 6, 85 (2011).
• 5) Mizoguchi K, Ikarashi Y. Cellular pharmacological effects of the traditional Japanese kampo medicine yokukansan on brain cells. Front. Pharmacol., 8, 655 (2017).

Terms in the title (5)： 抑肝散 ,  老化促進マウス ,  海馬 ,  依存性 ,  学習障害