Art

J-GLOBAL ID：201802249454562768   Reference number：18A1865504

Severe hypoxia increases expression of ATM and DNA-PKcs and it increases their activities through Src and AMPK signaling pathways

重度の低酸素症は,ATMおよびDNA-PKCSの発現を増加させ,それらのSrcおよびAMPKシグナル伝達経路を介してそれらの活性を増加させる【JST・京大機械翻訳】

Author (6)： Hashimoto Takuma (Department of Radiation Biology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan) ,  Murata Yasuhiko (Department of Radiation Biology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan) ,  Urushihara Yusuke (Department of Radiation Biology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan) ,  Shiga Soichiro (Department of Radiation Biology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan) ,  Takeda Kazuya (Department of Radiation Biology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan) ,  Hosoi Yoshio (Department of Radiation Biology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 505  Issue： 1  Page： 13-19  Publication year： 2018 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Solid tumors often contain hyp...

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Thesaurus term： *oxygen deficiency ,  *DNA ,  human ,  DNA double strand break ,  radiation resistance (radiation effect) ,  *Oxygen ,  Western blotting ,  radiosensitivity ,  fibroblast ,  tumor cell ,  solid tumor ,  *anoxia ,  siRNA ,  molecular mechanism ,  bioassay
Semi thesaurus term： 阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： Hypoxia ,  ATM ,  DNA-PKcs ,  Src ,  AMPK

JST classification (2)： Cell physiology in general  (EF02010S) ,  Gene expression  (EC02040Q)

Terms in the title (8)： 低酸素症 ,  ATM ,  DNA-PKcs ,  発現 ,  SRC ,  AMPK ,  シグナル伝達経路 ,  活性