Art

J-GLOBAL ID：201802249484227672   Reference number：18A0522275

DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1^P29S mutation

DOCK1阻害は自己活性化Rac1~P29S変異により誘導される癌細胞浸潤とマクロ飲作用を抑制する【Powered by NICT】

Author (20)： Tomino Takahiro (Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan) ,  Tomino Takahiro (Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan) ,  Tajiri Hirotada (Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan) ,  Tajiri Hirotada (Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan) ,  Tatsuguchi Takaaki (Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan) ,  Shirai Takahiro (Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Bunkyo-ku, Tokyo, 113-0033, Japan) ,  Oisaki Kounosuke (Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Bunkyo-ku, Tokyo, 113-0033, Japan) ,  Matsunaga Shigeki (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-ku, Sapporo, 060-0812, Japan) ,  Sanematsu Fumiyuki (Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan) ,  Sanematsu Fumiyuki (Research Center for Advanced Immunology, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan) ,  Sakata Daiji (Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan) ,  Sakata Daiji (Research Center for Advanced Immunology, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan) ,  Yoshizumi Tomoharu (Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan) ,  Maehara Yoshihiko (Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan) ,  Kanai Motomu (Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Bunkyo-ku, Tokyo, 113-0033, Japan) ,  Cote Jean-Francois (Institut de recherches cliniques de Montreal, Universite de Montreal, 110 avenue des Pins Ouest, Montreal, QC H2W 1R7, Canada) ,  Fukui Yoshinori (Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan) ,  Fukui Yoshinori (Research Center for Advanced Immunology, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan) ,  Uruno Takehito (Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan) ,  Uruno Takehito (Research Center for Advanced Immunology, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 497  Issue： 1  Page： 298-304  Publication year： 2018 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Rac1 is a member of the Rho fa...

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Thesaurus term： breast tumor ,  Phenotype ,  Cytoskeleton ,  GTPase ,  Melanoma ,  interaction ,  *immersional wetting ,  cell migration ,  targeting ,  human ,  Proteins ,  reconstitution ,  wild type ,  *DOCK180 protein ,  *Genetic Variation
Semi thesaurus term： *variation(biology) , 【Automatic Indexing@JST】

Author keywords (6)： Cancer ,  Rac1 ,  GEF ,  DOCK1 ,  Invasion ,  Cytoskeleton

JST classification (2)： Cell physiology in general  (EF02010S) ,  Function of cell components  (EF03060C)

Terms in the title (9)： DOCK1 ,  阻害 ,  自己 ,  活性化 ,  変異 ,  誘導 ,  癌細胞 ,  浸潤 ,  マクロ飲作用