Art

J-GLOBAL ID：201802250381646616   Reference number：18A1010909

Calcineurin B1 Deficiency in Glial Cells Induces Mucosal Degeneration and Inflammation in Mouse Small Intestine

グリア細胞におけるカルシニューリンB1欠損はマウス小腸における粘膜変性と炎症を誘発する

Author (6)： Fujita Maya (Department of Cellular Biophysics, Graduate School of Pharmaceutical Sciences, Nagoya City University) ,  Yagi Takaki (Department of Cellular Biophysics, Graduate School of Pharmaceutical Sciences, Nagoya City University) ,  Okura Umi (Department of Cellular Biophysics, Graduate School of Pharmaceutical Sciences, Nagoya City University) ,  Tanaka Jun'ichi (Department of Cellular Biophysics, Graduate School of Pharmaceutical Sciences, Nagoya City University) ,  Hirashima Naohide (Department of Cellular Biophysics, Graduate School of Pharmaceutical Sciences, Nagoya City University) ,  Tanaka Masahiko (Department of Cellular Biophysics, Graduate School of Pharmaceutical Sciences, Nagoya City University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 41  Issue： 5  Page： 786-796(J-STAGE)  Publication year： 2018 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *calcineurin ,...
Semi thesaurus term： GFAP ,...

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Author keywords (10)： calcineurin ,  enteric glial cell ,  small intestine ,  inflammation ,  nuclear factor of activated T cells (NFAT) ,  calcineurin ,  enteric glial cell ,  small intestine ,  inflammation ,  nuclear factor of activated T cells (NFAT)

JST classification (4)： Biological function  (EB03040U) ,  Laboratry organisms  (EA03070Y) ,  Gene manipulation  (EC02050B) ,  Basic medicine on digestive system  (GH01020E)

Reference (49)：

• 1) Rusnak F, Mertz P. Calcineurin: form and function. Physiol. Rev., 80, 1483-1521 (2000).
• 2) Groth RD, Dunbar RL, Mermelstein PG. Calcineurin regulation of neuronal plasticity. Biochem. Biophys. Res. Commun., 311, 1159-1171 (2003).
• 3) Tojima T, Hines JH, Henley JR, Kamiguchi H. Second messenger and membrane trafficking direct and organize growth cone steering. Nat. Rev. Neurosci., 12, 191-203 (2011).
• 4) Baumgärtel K, Mansuy IM. Neural functions of calcineurin in synaptic plasticity and memory. Learn. Mem., 19, 375-384 (2012).
• 5) Fernandez AM, Fernandez S, Carrero P, Garcia-Garcia M, Torres-Aleman I. Calcineurin in reactive astrocytes plays a key role in the interplay between proinflammatory and anti-inflammatory signals. J. Neurosci., 27, 8745-8756 (2007).

Terms in the title (9)： グリア細胞 ,  カルシニューリン ,  欠損 ,  マウス ,  小腸 ,  粘膜 ,  変性 ,  炎症 ,  誘発