Art

J-GLOBAL ID：201802250565764382   Reference number：18A1701420

A new method for simultaneous quantification of fosphenytoin, phenytoin and its primary metabolite 5-(4-hydroxyphenyl)-5-phenylhydantoin in whole blood by ultra-performance liquid chromatography-tandem mass spectrometry

超高速液体クロマトグラフィー-タンデム質量分析による全血中のホスフェニトインとフェニトインとその一次代謝産物5-(4-ヒドロキシフェニル)-5-フェニルヒダントインの同時定量のための新しい方法

Author (6)： Suzuki Takayoshi (Department of Legal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan) ,  Ogawa Tadashi (Department of Legal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan) ,  Ueyama Jun (Department of Pathophysiological Laboratory Sciences, Field of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Aichi 461-8673, Japan) ,  Iwai Masae (Department of Legal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan) ,  Kondo Fumio (Department of Legal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan) ,  Seno Hiroshi (Department of Legal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan)
Material： Legal Medicine  (Leg Med)
Volume： 34  Page： 64-69  Publication year： Sep. 2018 
JST Material Number： W1412A  ISSN： 1344-6223  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

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Author keywords (5)： Fosphenytoin ,  Phenytoin ,  Metabolite ,  Whole blood ,  Ultra-performance liquid chromatography-tandem mass spectrometry

JST classification (3)： Basic biopharmacy  (GY01021U) ,  Basic research of antiepileptics and anticonvulsants  (GW03060D) ,  Analysis of drugs  (GV01040Q)

Substance index (3)： 5-(4-Hydroxyphenyl)-5-phenylhydantoin ,  Phenytoin ,  Fosphenytoin

Terms in the title (7)： 高速液体クロマトグラフィー-タンデム質量分析 ,  全血 ,  ホスフェニトイン ,  フェニトイン ,  一次代謝産物 ,  5-フェニルヒダントイン ,  同時定量