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J-GLOBAL ID：201802251024030375   Reference number：18A0275603

Production of an active form of vitamin D₂ by genetically engineered CYP105A1

遺伝的に改変したCYP105A1によるビタミンD_2の活性型の生産【Powered by NICT】

Author (11)： Yasuda Kaori (Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan) ,  Yogo Yuya (Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan) ,  Sugimoto Hiroshi (RIKEN Spring-8 Center, Harima Institute, Sayo, Hyogo 679-5148, Japan) ,  Mano Hiroki (Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan) ,  Takita Teisuke (Division of Food Science and Technology, Graduate School of Agriculture, Kyoto University, KitashirakawaOiwake-cho, Sakyo-ku, Kyoto, 606-8502, Japan) ,  Ohta Miho (Department of Food and Nutrition Management Studies, Faculty of Human Development, Soai University, 4-4-1 Nanko-naka, Suminoe-ku, Osaka 559-0033, Japan) ,  Kamakura Masaki (Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan) ,  Ikushiro Shinichi (Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan) ,  Yasukawa Kiyoshi (Division of Food Science and Technology, Graduate School of Agriculture, Kyoto University, KitashirakawaOiwake-cho, Sakyo-ku, Kyoto, 606-8502, Japan) ,  Shiro Yoshitsugu (RIKEN Spring-8 Center, Harima Institute, Sayo, Hyogo 679-5148, Japan) ,  Sakaki Toshiyuki (Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 486  Issue： 2  Page： 336-341  Publication year： 2017 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Our previous studies revealed ...

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Thesaurus term： protein engineering ,  site-directed mutagenesis ,  crystal structure ,  catalyst ,  wild type ,  binding site ,  side chain ,  substrate(biochemistry) ,  hydroxylation ,  cytochrome P450 ,  *vitamin D ,  microorganism ,  *heredity
Semi thesaurus term： 残基 ,  *CYP105A1 , 【Automatic Indexing@JST】

Author keywords (5)： Cytochrome P450 ,  CYP105 ,  Protein engineering ,  Crystal structure ,  Active form of vitamin D₂

JST classification (2)： Enzyme in general  (EB09010D) ,  Vitamin D  (EB07050H)

Terms in the title (4)： 遺伝 ,  改変 ,  CYP105A1 ,  活性