Art

J-GLOBAL ID：201802251038021902   Reference number：18A1518083

Inhibition of astrocytic adenosine receptor A_2A attenuates microglial activation in a mouse model of Sandhoff disease

星状細胞アデノシン受容体A_2Aの阻害はSandhoff病のマウスモデルにおけるミクログリア活性化を減弱する【JST・京大機械翻訳】

Author (10)： Ogawa Yasuhiro (Department of Pharmacology, Meiji Pharmaceutical University, Tokyo 204-8588, Japan) ,  Furusawa Eiri (Department of Pharmacology, Meiji Pharmaceutical University, Tokyo 204-8588, Japan) ,  Saitoh Takahiro (Department of Pharmacology, Meiji Pharmaceutical University, Tokyo 204-8588, Japan) ,  Sugimoto Hiroki (Department of Pharmacology, Meiji Pharmaceutical University, Tokyo 204-8588, Japan) ,  Omori Takumi (Department of Pharmacology, Meiji Pharmaceutical University, Tokyo 204-8588, Japan) ,  Shimizu Shinya (Department of Pharmacology, Meiji Pharmaceutical University, Tokyo 204-8588, Japan) ,  Kondo Hisatsugu (Department of Pharmacology, Meiji Pharmaceutical University, Tokyo 204-8588, Japan) ,  Yamazaki Mika (Department of Pharmacology, Meiji Pharmaceutical University, Tokyo 204-8588, Japan) ,  Sakuraba Hitoshi (Department of Clinical Genetics, Meiji Pharmaceutical University, Tokyo 204-8588, Japan) ,  Oishi Kazuhiko (Department of Pharmacology, Meiji Pharmaceutical University, Tokyo 204-8588, Japan)
Material： Neurobiology of Disease  (Neurobiol Dis)
Volume： 118  Page： 142-154  Publication year： 2018 
JST Material Number： W1774A  ISSN： 0969-9961  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Astrocyte-microglia communicat...

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Thesaurus term： knockout mouse ,  enzyme activity ,  lysosome ,  inflammatory cytokine ,  Mutation ,  Phenotype ,  gene ,  chemokine ,  human ,  Inflammation ,  cerebral cortex ,  *microglia ,  *astrocyte ,  neuron ,  laboratory animal ,  Mus musculus ,  cortex ,  telencephalon
Semi thesaurus term： 慢性炎症 , 【Automatic Indexing@JST】

Author keywords (5)： Sandhoff disease ,  HexB knockout mice ,  Adenosine A_2A receptor ,  Astrogliosis ,  Istradefylline

JST classification (2)： Basic neurology  (GN01020W) ,  Cell physiology in general  (EF02010S)

Terms in the title (7)： 星状細胞 ,  アデノシン受容体 ,  阻害 ,  Sandhoff病 ,  マウスモデル ,  ミクログリア活性化 ,  減弱