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J-GLOBAL ID：201802252611558256   Reference number：18A0522032

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

喫煙行動のための大規模マルチ祖先ゲノムワイド研究会計は血圧のための複数の重要な遺伝子座【Powered by NICT】

Author (120)： Sung Yun J. (Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA) ,  Winkler Thomas W. (Department of Genetic Epidemiology, University of Regensburg, Regensburg 93051, Germany) ,  de las Fuentes Lisa (Cardiovascular Division, Department of Medicine, Washington University, St. Louis, MO 63110, USA) ,  Bentley Amy R. (Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA) ,  Brown Michael R. (Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, TX 77030, USA) ,  Kraja Aldi T. (Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA) ,  Schwander Karen (Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA) ,  Ntalla Ioanna (William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK) ,  Guo Xiuqing (Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA) ,  Franceschini Nora (Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27514, USA) ,  Lu Yingchang (Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USA) ,  Cheng Ching-Yu (Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore) ,  Cheng Ching-Yu (Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore 169857, Singapore) ,  Cheng Ching-Yu (Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore 117597, Singapore) ,  Sim Xueling (Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore 117549, Singapore) ,  Vojinovic Dina (Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands) ,  Marten Jonathan (Medical Research Council Human Genetics Unit, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK) ,  Musani Solomon K. (Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39213, USA) ,  Li Changwei (Department of Epidemiology and Biostatistics, University of Giorgia at Athens College of Public Health, Athens, GA 30602, USA) ,  Feitosa Mary F. (Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA) ,  Kilpelaeinen Tuomas O. (Section of Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark) ,  Kilpelaeinen Tuomas O. (Department of Environmental Medicine and Public Health, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Richard Melissa A. (Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA) ,  Noordam Raymond (Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300RC, the Netherlands) ,  Aslibekyan Stella (Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA) ,  Aschard Hugues (Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA) ,  Aschard Hugues (Centre de Bioinformatique Biostatistique et Biologie Integrative (C3BI), Institut Pasteur, Paris 75015, France) ,  Bartz Traci M. (Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, WA 98101, USA) ,  Dorajoo Rajkumar (Genome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, Singapore) ,  Liu Yongmei (Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA) ,  Manning Alisa K. (Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA 02114, USA) ,  Manning Alisa K. (Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA) ,  Rankinen Tuomo (Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA) ,  Smith Albert Vernon (Icelandic Heart Association, Kopavogur 201, Iceland) ,  Smith Albert Vernon (Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland) ,  Tajuddin Salman M. (Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA) ,  Tayo Bamidele O. (Department of Public Health Sciences, Loyola University Chicago, Maywood, IL 60153, USA) ,  Warren Helen R. (William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK) ,  Warren Helen R. (NIHR Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK) ,  Zhao Wei (School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA) ,  Zhou Yanhua (Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA) ,  Matoba Nana (Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan) ,  Sofer Tamar (Department of Biostatistics, University of Washington, Seattle, WA 98105, USA) ,  Alver Maris (Estonian Genome Center, University of Tartu, Tartu 51010, Estonia) ,  Amini Marzyeh (Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands) ,  Boissel Mathilde (CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille 59000, France) ,  Chai Jin Fang (Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore) ,  Chen Xu (Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden) ,  Divers Jasmin (Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA) ,  Gandin Ilaria (Department of Medical Sciences, University of Trieste, Trieste 34137, Italy) ,  Gao Chuan (Department of Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA) ,  Giulianini Franco (Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02215, USA) ,  Goel Anuj (Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire OX3 9DU, UK) ,  Goel Anuj (Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK) ,  Harris Sarah E. (Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK) ,  Harris Sarah E. (Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh EH4 2XU, UK) ,  Hartwig Fernando Pires (Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS 96020220, Brazil) ,  Horimoto Andrea R.V.R. (Lab Genetics and Molecular Cardiology, Department of Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, Brazil) ,  Hsu Fang-Chi (Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA) ,  Jackson Anne U. (Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA) ,  Kaehonen Mika (Department of Clinical Physiology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland) ,  Kaehonen Mika (Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland) ,  Kasturiratne Anuradhani (Department of Public Health, University of Kelaniya, Ragama, Sri Lanka) ,  Kuehnel Brigitte (Research Unit of Molecular Epidemiology, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg 85764, Germany) ,  Kuehnel Brigitte (Institute of Epidemiology II, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg 85764, Germany) ,  Leander Karin ,  Lee Wen-Jane ,  Lin Keng-Hung ,  Luan Jian'an ,  McKenzie Colin A. ,  Meian He ,  Nelson Christopher P. ,  Nelson Christopher P. ,  Rauramaa Rainer ,  Schupf Nicole ,  Scott Robert A. ,  Sheu Wayne H.H. ,  Sheu Wayne H.H. ,  Sheu Wayne H.H. ,  Sheu Wayne H.H. ,  Stancakova Alena ,  Takeuchi Fumihiko ,  van der Most Peter J. (Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands) ,  Varga Tibor V. ,  Wang Heming ,  Wang Yajuan ,  Ware Erin B. (School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA) ,  Ware Erin B. ,  Weiss Stefan ,  Weiss Stefan ,  Wen Wanqing ,  Yanek Lisa R. ,  Zhang Weihua ,  Zhang Weihua ,  Zhao Jing Hua ,  Afaq Saima ,  Alfred Tamuno (Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USA) ,  Amin Najaf (Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands) ,  Arking Dan ,  Aung Tin (Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore) ,  Aung Tin (Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore 169857, Singapore) ,  Aung Tin (Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore 117597, Singapore) ,  Barr R. Graham ,  Bielak Lawrence F. (School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA) ,  Boerwinkle Eric ,  Boerwinkle Eric ,  Bottinger Erwin P. (Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USA) ,  Braund Peter S. ,  Braund Peter S. ,  Brody Jennifer A. ,  Broeckel Ulrich ,  Cabrera Claudia P. (William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK) ,  Cabrera Claudia P. (NIHR Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK) ,  Cade Brian ,  Caizheng Yu ,  Campbell Archie ,  Canouil Mickaeel (CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille 59000, France) ,  Chakravarti Aravinda ,  Chauhan Ganesh ,  Christensen Kaare
Material： American Journal of Human Genetics  (AJHG)
Volume： 102  Issue： 3  Page： 375-400  Publication year： 2018 
JST Material Number： B0360B  ISSN： 0002-9297  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Genome-wide association analys...

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Thesaurus term： *genome ,  Europe ,  meta-analysis ,  cerebral apoplexy ,  deletion mutation ,  interaction ,  *smoking (tobacco) ,  *Blood Pressure ,  *gene ,  pathophysiology ,  Genome-Wide Association Study ,  Coronary Artery Disease ,  Africa ,  blood vessel ,  risk factor

Author keywords (6)： GWAS ,  GxE interactions ,  lifestyle ,  blood pressure ,  multi-ancestry ,  smoking

JST classification (1)： Cardiovascular system diseases  (GJ03000C)

Terms in the title (8)： 喫煙行動 ,  大規模 ,  マルチ ,  ゲノム ,  研究 ,  会計 ,  血圧 ,  遺伝子座