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J-GLOBAL ID：201802252939485072   Reference number：18A0387841

Long-term effects of maternal separation coupled with social isolation on reward seeking and changes in dopamine D1 receptor expression in the nucleus accumbens via DNA methylation in mice

マウスにおけるDNAメチル化を介して側坐核におけるドーパミンD1受容体発現の報酬探索と変化に関する社会的隔離と結合した母体分離の長期的影響【Powered by NICT】

Author (6)： Sasagawa Takayo (Department of Anatomy and Cell Biology, Nara Medical University, Kashihara, Nara, 634-8521, Japan) ,  Horii-Hayashi Noriko (Department of Anatomy and Cell Biology, Nara Medical University, Kashihara, Nara, 634-8521, Japan) ,  Okuda Akinori (Department of Orthopedic Surgery, Nara Medical University, Kashihara, Nara, 634-8521, Japan) ,  Hashimoto Takashi (Department of Anatomy, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui, 910-1193, Japan) ,  Azuma Cho (Department of Anatomy and Cell Biology, Nara Medical University, Kashihara, Nara, 634-8521, Japan) ,  Nishi Mayumi (Department of Anatomy and Cell Biology, Nara Medical University, Kashihara, Nara, 634-8521, Japan)
Material： Neuroscience Letters  (Neurosci Lett)
Volume： 641  Page： 33-39  Publication year： 2017 
JST Material Number： W0118A  ISSN： 0304-3940  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Early-life stress has long-las...

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Thesaurus term： adult(development) ,  D2 receptor ,  Rodentia ,  mRNA ,  *methylation ,  exploratory behavior ,  down-regulation ,  promoter(genetics) ,  *D1 receptor ,  epigenetics ,  *social isolation ,  *nucleus accumbens ,  catecholamine ,  primary amine
Semi thesaurus term： 若年 ,  *DNAメチル化 , 【Automatic Indexing@JST】

Author keywords (5)： Conditioned place preference ,  Dopamine receptor ,  Early-life stress ,  Epigenetics ,  Reward

JST classification (1)： Central nervous system  (EJ12030F)

Substance index (1)： Dopamine

Terms in the title (10)： マウス ,  DNAメチル化 ,  側坐核 ,  ドーパミンD1受容体 ,  発現 ,  報酬 ,  探索 ,  社会的隔離 ,  母体 ,  長期