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J-GLOBAL ID：201802253565160594   Reference number：18A0473053

Thermo-triggered Release of CRISPR-Cas9 System by Lipid-Encapsulated Gold Nanoparticles for Tumor Therapy

腫瘍治療のためのな脂質-カプセル化金ナノ粒子によるCRISPR-Cas9システムの熱誘起放出【Powered by NICT】

Author (17)： Wang Peng (CAS Center for Excellence in Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No. 11, BeiYiTiao, ZhongGuanCun, Beijing, 100190, China) ,  Zhang Lingmin (CAS Center for Excellence in Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No. 11, BeiYiTiao, ZhongGuanCun, Beijing, 100190, China) ,  Zhang Lingmin (Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Third & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 511436, China) ,  Zheng Wenfu (CAS Center for Excellence in Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No. 11, BeiYiTiao, ZhongGuanCun, Beijing, 100190, China) ,  Cong Liman (Department of Nano-Medical Science, Graduate School of Medicine, Tohoku University, Sendai, 980-8575, Japan) ,  Guo Zhaorong (Department of Nano-Medical Science, Graduate School of Medicine, Tohoku University, Sendai, 980-8575, Japan) ,  Xie Yangzhouyun (CAS Center for Excellence in Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No. 11, BeiYiTiao, ZhongGuanCun, Beijing, 100190, China) ,  Wang Le (CAS Center for Excellence in Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No. 11, BeiYiTiao, ZhongGuanCun, Beijing, 100190, China) ,  Tang Rongbing (CAS Center for Excellence in Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No. 11, BeiYiTiao, ZhongGuanCun, Beijing, 100190, China) ,  Feng Qiang (CAS Center for Excellence in Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No. 11, BeiYiTiao, ZhongGuanCun, Beijing, 100190, China) ,  Hamada Yoh (Department of Nano-Medical Science, Graduate School of Medicine, Tohoku University, Sendai, 980-8575, Japan) ,  Gonda Kohsuke (Department of Nano-Medical Science, Graduate School of Medicine, Tohoku University, Sendai, 980-8575, Japan) ,  Hu Zhijian (CAS Center for Excellence in Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No. 11, BeiYiTiao, ZhongGuanCun, Beijing, 100190, China) ,  Wu Xiaochun (CAS Center for Excellence in Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No. 11, BeiYiTiao, ZhongGuanCun, Beijing, 100190, China) ,  Jiang Xingyu (CAS Center for Excellence in Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No. 11, BeiYiTiao, ZhongGuanCun, Beijing, 100190, China) ,  Jiang Xingyu (Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Third & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 511436, China) ,  Jiang Xingyu (University of Chinese Academy of Sciences, Beijing, 100049, China)
Material： Angewandte Chemie. International Edition  (Angewandte Chemie. International Edition in English)
Volume： 57  Issue： 6  Page： 1491-1496  Publication year： 2018 
JST Material Number： H0127B  ISSN： 1433-7851  CODEN： ACIEAY  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： CRISPR/Cas9 system is a powerf...

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Thesaurus term： *lipid ,  tumor cell ,  plasmid ,  *tumor ,  Melanoma ,  Cytosol ,  electrostatic interaction ,  condensation ,  covering ,  target gene ,  *CRISPR ,  *gold nanoparticle ,  *Cas9 protein
Semi thesaurus term： 多機能 ,  *Cas9 ,  *腫瘍治療 , 【Automatic Indexing@JST】

Author keywords (5)： CRISPR/Cas9 delivery ,  gold nanoparticles ,  lipids ,  photothermal effect ,  tumor therapy

JST classification (2)： Molecular compounds  (CE02000C) ,  Colloid chemistry in general  (CB11010C)

Terms in the title (7)： 腫瘍治療 ,  脂質 ,  カプセル化 ,  金ナノ粒子 ,  CRISPR-Cas9システム ,  誘起 ,  放出