Art

J-GLOBAL ID：201802253683021565   Reference number：18A1361304

Novel androgen receptor full antagonists: Design, synthesis, and a docking study of glycerol and aminoglycerol derivatives that contain p-carborane cages

新規アンドロゲン受容体完全アンタゴニスト: p-カルボランケージを含むグリセロールおよびアミノグリセロール誘導体の設計,合成およびドッキング研究【JST・京大機械翻訳】

Author (6)： Kaise Asako (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan) ,  Ohta Kiminori (School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan) ,  Fujii Shinya (Institute of Molecular and Cellular Bioscience, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan) ,  Oda Akifumi (Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tenpaku-ku, Nagoya 468-8503, Japan) ,  Goto Tokuhito (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan) ,  Endo Yasuyuki (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 26  Issue： 13  Page： 3805-3811  Publication year： 2018 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Based on the co-crystal struct...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=18A1361304&from=J-GLOBAL&jstjournalNo=W0556A") }}

Thesaurus term： *docking ,  antagonism ,  secondary structure ,  *carborane ,  isomer (molecule) ,  *androgen receptor ,  Aminoglycosides ,  controlling element ,  LNCaP cell ,  co-crystal ,  inhibitory activity ,  Genetic Variation ,  aliphatic alcohol ,  polyol ,  sulfone ,  aromatic amine ,  aromatic fluorine compound ,  carboxamide ,  aromatic nitrile ,  hydroxy acid
Semi thesaurus term： variation(biology) ,  *アンタゴニスト , 【Automatic Indexing@JST】

Author keywords (4)： Androgen receptor ,  Hydrophobic pharmacophore ,  Carborane ,  Anti-androgen withdrawal syndrome

JST classification (3)： Structure-activity relationship of drugs  (GV01050B) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Molecular and genetic information processing  (JE15040B)

Substance index (2)： Glycerol ,  Bicalutamide

Terms in the title (7)： アンドロゲン受容体 ,  アンタゴニスト ,  グリセロール ,  誘導体 ,  設計 ,  ドッキング ,  研究