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J-GLOBAL ID：201802253736119583   Reference number：18A1670111

Andrographolide from Andrographis paniculata shows anti-proliferative activity and anti-inflammatory effects in human monocytic leukemia cells

Andrographis paniculata由来のアンドログラホリドはヒト単球性白血病細胞において抗増殖活性と抗炎症効果を示す

Author (9)： Doi Hiroki (Faculty of Medical Technology, Fujita Health University Graduate School of Health Sciences) ,  Matsui Taei (Faculty of Medical Technology, Fujita Health University Graduate School of Health Sciences) ,  Ohye Tamae (Faculty of Medical Technology, Fujita Health University Graduate School of Health Sciences) ,  Imamura Seiji (Faculty of Medical Technology, Fujita Health University School of Health Sciences) ,  Higashimoto Yuki (Faculty of Medical Technology, Fujita Health University School of Health Sciences) ,  Yukitake Jun (Faculty of Medical Technology, Fujita Health University Graduate School of Health Sciences) ,  Saito Kuniaki (Faculty of Medical Technology, Fujita Health University Graduate School of Health Sciences) ,  Katsuda Itsuro (Department of Hematology, Fujita Health University, School of Medicine) ,  Akiyama Hidehiko (Faculty of Medical Technology, Fujita Health University Graduate School of Health Sciences)
Material： Fujita Medical Journal (Web)  (Fujita Med J (Web))
Volume： 4  Issue： 3  Page： 55-60(J-STAGE)  Publication year： 2018 
JST Material Number： U0775A  ISSN： 2189-7255  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Acanthaceae ,...
Semi thesaurus term： *Andrographis paniculata ,...

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Author keywords (5)： Andrographis paniculata ,  Andrographolide ,  Human monocytic leukemia cells ,  Inflammatory cytokine ,  NF-κB

JST classification (2)： Basic research of pharmacology of crude drugs  (GX06020J) ,  Experimental treatment for tumors  (GE02040Y)

Substance index (1)： Andrographolide

Reference (19)：

• 1. Akbar S. Andrographis paniculata: a review of pharmacological activities and clinical effects. Altern Med Rev 2011; 16: 66-77.
• 2. Varma A, Padh H, Shrivastava N. Andrographolide: a new plant-derived antineoplastic entity on horizon. Evid Based Complement Alternat Med 2011; 2011: 815390. doi: 10.1093/ecam/nep135. (epub ahead of print)
• 3. Lim JC, Chan TK, Ng DS, Sagineedu SR, Stanslas J, Wong WS. Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer. Clin Exp Pharmacol Physiol 2012; 39: 300-310.
• 4. Li J, Cheung HY, Zhang Z, Chan GK, Fong WF. Andrographolide induces cell cycle arrest at G2/M phase and cell death in HepG2 cells via alteration of reactive oxygen species. Eur J Pharmacol 2007; 568: 31-44.
• 5. Dai L, Wang G, Pan W. Andrographolide inhibits proliferation and metastasis of SGC7901 gastric cancer cells. Biomed Res Int 2017; 1-10. doi: 10.1155/2017/6242103. (epub ahead of print)

Terms in the title (6)： Andrographis ,  アンドログラホリド ,  ヒト単球 ,  白血病細胞 ,  抗増殖活性 ,  抗炎症効果