Art

J-GLOBAL ID：201802254035206500   Reference number：18A1153432

Identification of deleterious rare variants in MTTP , PNPLA3 , and TM6SF2 in Japanese males and association studies with NAFLD

日本人男性におけるMTTP,PNPLA3およびTM6SF2の有害な稀な変異体の同定およびNAFLDとの関連研究【JST・京大機械翻訳】

Author (7)： Boonvisut Supichaya (Division of Human Genetics, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan) ,  Boonvisut Supichaya (The Chulabhorn Graduate Institute, Bangkok, Thailand) ,  Yoshida Ken (Division of Human Genetics, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan) ,  Nakayama Kazuhiro (Division of Human Genetics, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan) ,  Watanabe Kazuhisa (Division of Human Genetics, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan) ,  Miyashita Hiroshi (Jichi Medical University Health Care Center, Tochigi, Japan) ,  Iwamoto Sadahiko (Division of Human Genetics, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan)
Material： Lipids in Health and Disease (Web)
Volume： 16  Issue： 1  Page： 183  Publication year： 2017 
JST Material Number： U7391A  ISSN： 1476-511X  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Background Non-alcoholic fatty...

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Thesaurus term： drinking ,  hepatocyte ,  gene ,  sensitivity ,  Genotype ,  *man ,  Heredity ,  in vitro experiment ,  single nucleotide polymorphism ,  gene frequency ,  Genetic Association Studies ,  *Japanese ,  population genetics
Semi thesaurus term： オッズ比 ,  再配列 ,  *非アルコール性脂肪性肝疾患 , 【Automatic Indexing@JST】

Author keywords (4)： Non-alcoholic fatty liver disease ,  Rare variants ,  Re-sequencing ,  Association study

JST classification (2)： Digestive system diseases  (GH03000W) ,  Genetic variation  (EC01030Y)

Reference (24)：

• N Engl J Med; Nonalcoholic fatty liver disease; P Angulo; 346; 2002; 1221-1231; 10.1056/NEJMra011775; CR1;
• Nutrients; Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease; M Gaggini, M Morelli, M Buzzigoli, RA DeFronzo, E Bugianesi, A Gastaldelli; 5; 2013; 1544-1560; 10.3390/nu5051544; CR2;
• J Gastroenterol Hepatol; Fatty liver and the metabolic syndrome among Shanghai adults; JG Fan, J Zhu, XJ Li, L Chen, YS Lu; 20; 2005; 1825-1832; 10.1111/j.1440-1746.2005.04058.x; CR3;
• Curr Pharm; Genetic predisposition in NAFLD and NASH: impact on severity of liver disease and response to treatment; P Dongiovanni, QM Anstee, L Valenti; 19; 2013; 5219-5238; 10.2174/13816128113199990381; CR4;
• Gastroenterology; Heritability of nonalcoholic fatty liver disease; JB Schwimmer, MA Celedon, JE Lavine, R Salem, N Campbell, NJ Schork; 136; 2009; 1585-1592; 10.1053/j.gastro.2009.01.050; CR5;

Terms in the title (7)： 日本人 ,  男性 ,  PNPLA3 ,  変異体 ,  同定 ,  NAFLD ,  研究