Art

J-GLOBAL ID：201802254324709456   Reference number：18A0267844

Picrasidine G decreases viability of MDA-MB 468 EGFR-overexpressing triple-negative breast cancer cells through inhibition of EGFR/STAT3 signaling pathway

Picrasidine GはEGFR/STAT3シグナル伝達経路の阻害を介してMDA-468EGFRを過剰発現するトリプルネガティブ乳癌細胞の生存率を低下させる【Powered by NICT】

Author (7)： Yamashita Naoya (Department of Molecular Toxicology, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan) ,  Kondo Manami (Department of Molecular Toxicology, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan) ,  Zhao Shuai (Department of Molecular Toxicology, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan) ,  Li Wei (Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan) ,  Koike Kazuo (Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan) ,  Nemoto Kiyomitsu (Department of Molecular Toxicology, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan) ,  Kanno Yuichiro (Department of Molecular Toxicology, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 27  Issue： 11  Page： 2608-2612  Publication year： 2017 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Targeted therapy is unavailabl...

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Thesaurus term： caspase ,  *breast tumor ,  *EGF receptor ,  molecular target therapy ,  phosphorylation ,  *survival ratio ,  patient ,  apoptosis
Semi thesaurus term： 標的遺伝子 ,  サバイビン ,  カスパーゼ3 ,  *乳癌細胞 ,  *トリプルネガティブ乳癌 ,  *過剰発現 ,  *STAT3転写因子 , 【Automatic Indexing@JST】

Author keywords (5)： Breast cancer ,  Epidermal growth factor receptor ,  Signal transducer and activator of transcription 3 ,  Apoptosis ,  Caspase

JST classification (2)： Synthesis of drugs  (GV01030F) ,  Structure-activity relationship of drugs  (GV01050B)

Terms in the title (9)： EGFR ,  STAT3 ,  シグナル伝達経路 ,  阻害 ,  MDA ,  過剰発現 ,  トリプルネガティブ乳癌 ,  細胞 ,  生存