Art

J-GLOBAL ID：201802254572337308   Reference number：18A0855295

4-Substituted carbamazepine derivatives: Conformational analysis and sodium channel-blocking properties

4-置換カルバマゼピン誘導体 配座解析とナトリウムチャンネル遮断特性【JST・京大機械翻訳】

Author (9)： Kanase Yuki (Faculty of Pharma Sciences, Teikyo University, 2-11-1, Kaga, Itabashi-ku, Tokyo 173-8605, Japan) ,  Kitada Takafumi (Faculty of Pharma Sciences, Teikyo University, 2-11-1, Kaga, Itabashi-ku, Tokyo 173-8605, Japan) ,  Tabata Hidetsugu (Faculty of Pharma Sciences, Teikyo University, 2-11-1, Kaga, Itabashi-ku, Tokyo 173-8605, Japan) ,  Makino Kosho (Faculty of Pharma Sciences, Teikyo University, 2-11-1, Kaga, Itabashi-ku, Tokyo 173-8605, Japan) ,  Oshitari Tetsuta (Faculty of Pharma Sciences, Teikyo University, 2-11-1, Kaga, Itabashi-ku, Tokyo 173-8605, Japan) ,  Ohashi Hiromi (Preclinical Safety Research Unit, Tsukuba R&D Supporting Division, Sunplanet Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki, Japan) ,  Yoshinaga Takashi (Global Cardiovascular Assessment, Biopharmaceutical Assessment Core Function Unit, Medicine Development Center, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki, Japan) ,  Natsugari Hideaki (Faculty of Pharma Sciences, Teikyo University, 2-11-1, Kaga, Itabashi-ku, Tokyo 173-8605, Japan) ,  Takahashi Hideyo (Faculty of Pharma Sciences, Teikyo University, 2-11-1, Kaga, Itabashi-ku, Tokyo 173-8605, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 26  Issue： 9  Page： 2508-2513  Publication year： 2018 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The physicochemical properties...

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Thesaurus term： electric current ,  *sodium channel ,  *conformational analysis ,  enantiomer ,  atropisomerism ,  atropisomer ,  nitrogen heterocyclic compound ,  urea compound ,  polynuclear aromatic compound
Semi thesaurus term： 化学的安定性 ,  物理化学的性質 ,  *遮断 , 【Automatic Indexing@JST】

Author keywords (4)： Atropisomerism ,  Carbamazepine ,  Urea ,  Sodium channel

JST classification (2)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Synthesis of drugs  (GV01030F)

Substance index (1)： Carbamazepine

Terms in the title (6)： 置換 ,  カルバマゼピン ,  誘導体 ,  配座解析 ,  ナトリウムチャンネル ,  遮断