Art

J-GLOBAL ID：201802255899217622   Reference number：18A0475934

A Novel Prodrug of a γ-Glutamylcyclotransferase Inhibitor Suppresses Cancer Cell Proliferation in vitro and Inhibits Tumor Growth in a Xenograft Mouse Model of Prostate Cancer

γ グルタミルシクロトランスフェラーゼ阻害剤の新規プロドラッグ前立腺癌の異種移植片マウスモデルにおけるin vitroでの癌細胞増殖を阻害する腫瘍増殖を抑制する【Powered by NICT】

Author (13)： Ii Hiromi (Department of Clinical Oncology, Kyoto Pharmaceutical University, Misasagi-Nakauchicho 5, Yamashina-ku, Kyoto, 607-8414, Japan) ,  Yoshiya Taku (Peptide Institute Inc., 7-2-9 Saito-Asagi, Ibaraki-shi, Osaka, 567-0085, Japan) ,  Nakata Susumu (Department of Clinical Oncology, Kyoto Pharmaceutical University, Misasagi-Nakauchicho 5, Yamashina-ku, Kyoto, 607-8414, Japan) ,  Taniguchi Keiko (Department of Clinical Oncology, Kyoto Pharmaceutical University, Misasagi-Nakauchicho 5, Yamashina-ku, Kyoto, 607-8414, Japan) ,  Hidaka Koushi (Faculty of Pharmaceutical Sciences, Cooperative Research Center of Life Sciences, Kobe Gakuin University, 1-1-3 Minatojima, Chuo-ku, Kobe, 650-8586, Japan) ,  Tsuda Shugo (Peptide Institute Inc., 7-2-9 Saito-Asagi, Ibaraki-shi, Osaka, 567-0085, Japan) ,  Mochizuki Masayoshi (Peptide Institute Inc., 7-2-9 Saito-Asagi, Ibaraki-shi, Osaka, 567-0085, Japan) ,  Nishiuchi Yuji (Peptide Institute Inc., 7-2-9 Saito-Asagi, Ibaraki-shi, Osaka, 567-0085, Japan) ,  Nishiuchi Yuji (Present address: GlyTech Inc., 134 Chudoji Minamimachi, KRP #1-109, Shimogyo-ku, Kyoto, 600-8813, Japan) ,  Tsuda Yuko (Faculty of Pharmaceutical Sciences, Cooperative Research Center of Life Sciences, Kobe Gakuin University, 1-1-3 Minatojima, Chuo-ku, Kobe, 650-8586, Japan) ,  Ito Kosei (Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 852-8588, Japan) ,  Kageyama Susumu (Department of Urology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan) ,  Yoshiki Tatsuhiro (Department of Clinical Oncology, Kyoto Pharmaceutical University, Misasagi-Nakauchicho 5, Yamashina-ku, Kyoto, 607-8414, Japan)
Material： ChemMedChem
Volume： 13  Issue： 2  Page： 155-163  Publication year： 2018 
JST Material Number： W1573A  ISSN： 1860-7179  CODEN： CHEMGX  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： γ-Glutamylcyclotransferase (GG...

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Thesaurus term： human(primates) ,  therapeutic planning ,  *prostatic tumor ,  *heterotrans plantation ,  enzyme activity ,  *prodrug ,  *tumor cell ,  antitumor action ,  *tumor
Semi thesaurus term： 過剰発現 ,  蛍光色素 ,  *マウスモデル ,  *異種移植片 ,  *阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： antitumor agents ,  membrane permeability ,  prodrugs ,  N-glutaryl-l-alanine ,  γ-glutamylcyclotransferase

JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Terms in the title (9)： 阻害剤 ,  プロドラッグ ,  前立腺癌 ,  異種移植片 ,  マウスモデル ,  癌細胞 ,  増殖 ,  阻害 ,  腫瘍増殖