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J-GLOBAL ID：201802255944562618   Reference number：18A1780446

Combinatorial CRISPR/Cas9 Approach to Elucidate a Far-Upstream Enhancer Complex for Tissue-Specific Sox9 Expression

組織特異的Sox9発現のための遠上流エンハンサー複合体を解明するための組合せCRISPR/Cas9アプローチ【JST・京大機械翻訳】

Author (15)： Mochizuki Yusuke (Department of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan) ,  Mochizuki Yusuke (Department of Orthopaedic Surgery, Nippon Medical School, Tokyo 113-0022, Japan) ,  Chiba Tomoki (Department of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan) ,  Kataoka Kensuke (Department of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan) ,  Yamashita Satoshi (Department of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan) ,  Sato Tempei (Department of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan) ,  Kato Tomomi (Department of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan) ,  Takahashi Kenji (Department of Orthopaedic Surgery, Nippon Medical School, Tokyo 113-0022, Japan) ,  Miyamoto Takeshi (Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo 160-0016, Japan) ,  Kitazawa Masashi (Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo 135-0064, Japan) ,  Hatta Tomohisa (Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo 135-0064, Japan) ,  Natsume Tohru (Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo 135-0064, Japan) ,  Takai Shinro (Department of Orthopaedic Surgery, Nippon Medical School, Tokyo 113-0022, Japan) ,  Asahara Hiroshi (Department of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan) ,  Asahara Hiroshi (Department of Molecular and Experimental Medicine, The Scripps Research Institute, San Diego, CA 92037, USA)
Material： Developmental Cell  (Dev Cell)
Volume： 46  Issue： 6  Page： 794-806.e6  Publication year： 2018 
JST Material Number： W1692A  ISSN： 1534-5807  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： SRY-box 9 (SOX9) is a master t...

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Thesaurus term： mass spectrometry ,  steric conformation ,  chromatin ,  cartilage ,  *complex(substance) ,  promoter(genetics) ,  patient ,  enhancer ,  cellular signal transduction ,  transcription factor ,  gene silencing
Semi thesaurus term： *SOX9転写因子 ,  シスエレメント ,  ハプロ不全 ,  *Cas9 , 【Automatic Indexing@JST】

Author keywords (11)： SRY-box 9 ,  Sox9 ,  cartilage ,  acampomelic campomelic dysplasia ,  ACD ,  enhancer ,  clustered regularly interspaced short palindromic repeats ,  CRISPR ,  transcription complex ,  signal transducer and activator of transcription 3 ,  Stat3

JST classification (2)： Biological function  (EB03040U) ,  Development(=generation)and differentiation  (EJ16020W)

Terms in the title (8)： 組織 ,  Sox9 ,  発現 ,  上流 ,  複合体 ,  組合せ ,  CRISPR ,  Cas9