Art

J-GLOBAL ID：201802256034848915   Reference number：18A1913646

Involvement of Catechols in Acteoside in the Activation of Promatrix Metalloproteinase-2 and Membrane Type-1-Matrix Metalloproteinase Expression via a Phosphatidylinositol-3-Kinase Pathway in Human Dermal Fibroblasts

ヒト皮膚線維芽細胞におけるホスファチジルイノシトール-3-キナーゼ経路を介したプロマトリックスメタロプロテイナーゼ-2および膜1型マトリックスメタロプロテイナーゼの発現の活性化に対するアクテオシドにおけるカテコールの関与

Author (11)： Si Nan (Department of Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Si Nan (Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences) ,  Kanazawa Hajime (Department of Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Okuyama Katsuki (Department of Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Imada Keisuke (Department of Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Wang Hongjie (Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences) ,  Yang Jian (Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences) ,  Zhao Haiyu (Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences) ,  Bian Baolin (Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences) ,  Ito Akira (The Institute for Social Medicine,Tokyo University of Pharmacy and Life Sciences) ,  Sato Takashi (Department of Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 41  Issue： 10  Page： 1530-1536(J-STAGE)  Publication year： 2018 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： skin fibroblast ,...

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Author keywords (10)： acteoside ,  dermal fibroblast ,  matrix metalloproteinase ,  granulation tissue formation ,  extracellular matrix ,  acteoside ,  dermal fibroblast ,  matrix metalloproteinase ,  granulation tissue formation ,  extracellular matrix

JST classification (4)： Basic dermatology  (GF01020Y) ,  Integument in general  (EJ11010C) ,  Basic research of pharmacology of crude drugs  (GX06020J) ,  Basic research of drugs acting on integumentum commune  (GW12010Y)

Substance index (4)： Acteoside ,  Catechol ,  Hydroxytyrosol ,  LY-294002

Reference (30)：

• 1) Tracy LE, Minasian RA, Caterson EJ. Extracellular matrix and dermal fibroblast function in the healing wound. Adv. Wound Care (New Rochelle), 5, 119-136 (2016).
• 2) Krishnaswamy VR, Mintz D, Sagi I. Matrix metalloproteinases: The sculptors of chronic cutaneous wounds. Biochim. Biophys. Acta, 1864 (11 Pt B), 2220-2227 (2017).
• 3) Iocono JA, Colleran KR, Remick DG, Gillespie BW, Ehrlich HP, Garner WL. Interleukin-8 levels and activity in delayed-healing human thermal wounds. Wound Repair Regen., 8, 216-225 (2000).
• 4) Trengove NJ, Bielefeldt-Ohmann H, Stacey MC. Mitogenic activity and cytokine levels in non-healing and healing chronic leg ulcers. Wound Repair Regen., 8, 13-25 (2000).
• 5) Itoh Y. Membrane-type matrix metalloproteinases: Their functions and regulations. Matrix Biol., 44-46, 207-223 (2015).

Terms in the title (11)： ヒト ,  皮膚線維芽細胞 ,  ホスファチジルイノシトール ,  キナーゼ ,  経路 ,  マトリックスメタロプロテイナーゼ-2 ,  マトリックスメタロプロテイナーゼ ,  発現 ,  活性化 ,  アクテオシド ,  カテコール