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J-GLOBAL ID：201802256181838283   Reference number：18A0612440

Decreased Skin Barrier Lipid Acylceramide and Differentiation-Dependent Gene Expression in Ichthyosis Gene Nipal4-Knockout Mice

魚鱗癬遺伝子Nipal4ノックアウトマウスにおける低下した皮膚バリア脂質Acylceramideと分化依存遺伝子発現【Powered by NICT】

Author (7)： Honda Yuichi (Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan) ,  Kitamura Takuya (Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan) ,  Naganuma Tatsuro (Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan) ,  Abe Takaya (Animal Resource Development Unit and Genetic Engineering Team, RIKEN Center for Life Science Technologies, Kobe, Japan) ,  Ohno Yusuke (Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan) ,  Sassa Takayuki (Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan) ,  Kihara Akio (Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan)
Material： Journal of Investigative Dermatology  (J Invest Dermatol)
Volume： 138  Issue： 4  Page： 741-749  Publication year： 2018 
JST Material Number： H0776A  ISSN： 0022-202X  CODEN： JIDEAE  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： NIPAL4 is one of the causative...

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Thesaurus term： neonate ,  *differentiation (biology) ,  *ichthyosis ,  *knockout mouse ,  Pathology ,  *lipid ,  *gene ,  *gene expression ,  autosome ,  keratinocyte ,  chromatin remodeling ,  molecular mechanism ,  causative gene ,  Genetic Variation ,  *laboratory animal ,  *Mus musculus ,  *molecular genetic phenomenon
Semi thesaurus term： variation(biology) ,  *皮膚バリアー機能 , 【Automatic Indexing@JST】

JST classification (2)： Integument in general  (EJ11010C) ,  Congenital diseases,deformities in general.  (GD03010V)

Terms in the title (7)： 魚鱗癬 ,  遺伝子 ,  ノックアウトマウス ,  皮膚バリア ,  脂質 ,  分化 ,  遺伝子発現