Art

J-GLOBAL ID：201802256685542488   Reference number：18A0574458

Angiotensin-II regulates dosing time-dependent intratumoral accumulation of macromolecular drug formulations via 24-h blood pressure rhythm in tumor-bearing mice

アンギオテンシンIIは担癌マウスにおける24時間血圧リズムによる高分子薬物製剤の投与時間依存性腫瘍内蓄積を調節する【Powered by NICT】

Author (11)： Matsunaga Takashi (Department of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka, 812-8512, Japan) ,  Matsunaga Naoya (Department of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka, 812-8512, Japan) ,  Matsunaga Naoya (Department of Glocal Healthcare Science, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan) ,  Kusunose Naoki (Department of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka, 812-8512, Japan) ,  Ikeda Eriko (Department of Molecular Biology, Daiichi University of Pharmacy, Minami-ku, Fukuoka, 815-8511, Japan) ,  Okazaki Hiroyuki (Department of Molecular Biology, Daiichi University of Pharmacy, Minami-ku, Fukuoka, 815-8511, Japan) ,  Kakimoto Keisuke (Department of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka, 812-8512, Japan) ,  Hamamura Kengo (First Department of Pharmacology, Daiichi University of Pharmacy, Minami-ku, Fukuoka, 815-8511, Japan) ,  Koyanagi Satoru (Department of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka, 812-8512, Japan) ,  Koyanagi Satoru (Department of Glocal Healthcare Science, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan) ,  Ohdo Shigehiro (Department of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka, 812-8512, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 498  Issue： 1  Page： 86-91  Publication year： 2018 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： One approach to increasing pha...

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Thesaurus term： *macromolecule ,  *tumor ,  *blood pressure ,  *pharmaceutical preparation ,  liposome ,  gene ,  high molecular weight ,  *administration(biology) ,  systolic blood pressure ,  pharmacokinetics ,  *time dependence ,  *angiotensin II ,  drug therapy ,  diurnal rhythm
Semi thesaurus term： *投与時間 , 【Automatic Indexing@JST】

Author keywords (5)： Blood pressure ,  Circadian rhythm ,  EPR effect ,  Intratumoral accumulation ,  Liposome

JST classification (3)： Cardiovascular system diseases  (GJ03000C) ,  Kidney  (EJ09030X) ,  Basic research of vasoactive drugs and hypotensive drugs  (GW07040J)

Terms in the title (12)： アンギオテンシンII ,  担癌マウス ,  24時間血圧 ,  リズム ,  高分子 ,  薬物 ,  製剤 ,  投与 ,  時間依存性 ,  腫瘍 ,  蓄積 ,  調節