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J-GLOBAL ID：201802256861821931   Reference number：18A0235999

Development of genotyping method for functionally relevant variants of cytochromes P450 in cynomolgus macaques

カニクイザルにおけるチトクロームP450の機能的に関連した変異体の遺伝子型決定法の開発【Powered by NICT】

Author (7)： Uno Y. (Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd., Kainan, Japan) ,  Osada N. (Graduate School of Bioengineering and Bioinformatics, Graduate School of Information Science and Technology, Hokkaido University, Sapporo, Japan) ,  Sakurai S. (Graduate School of Bioengineering and Bioinformatics, Graduate School of Information Science and Technology, Hokkaido University, Sapporo, Japan) ,  Shimozawa N. (Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, Japan) ,  Iwata T. (Division of Molecular and Cellular Biology, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Tokyo, Japan) ,  Ikeo K. (National Institute of Genetics, Mishima, Japan) ,  Yamazaki H. (Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan)
Material： Journal of Veterinary Pharmacology and Therapeutics  (J Vet Pharmacol Ther)
Volume： 41  Issue： 1  Page： e30-e34  Publication year： 2018 
JST Material Number： W1722A  ISSN： 0140-7783  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： In cynomolgus macaques (Macaca...

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Thesaurus term： real time polymerase chain reaction ,  drug metabolism ,  *genotype ,  drug metabolizing enzyme ,  Republic of the Philippines ,  animal ,  *variation(biology) ,  Kingdom of Cambodia ,  substrate(biochemistry) ,  wild type ,  Socialist Republic of Viet Nam ,  *cytochrome P450 ,  DNA ,  *Macaca fascicularis ,  Republic of Indonesia

Author keywords (5)： cytochrome P450 ,  genotyping ,  monkey ,  polymorphisms ,  real-time polymerase chain reaction

JST classification (1)： Enzyme physiology  (EJ02020P)

Terms in the title (5)： カニクイザル ,  チトクロームP450 ,  変異体 ,  遺伝子型決定法 ,  開発