Art

J-GLOBAL ID：201802257353019180   Reference number：18A1247724

Nonstructural protein of severe fever with thrombocytopenia syndrome phlebovirus targets STAT2 and not STAT1 to inhibit type I interferon-stimulated JAK-STAT signaling

血小板減少症候群Phlebovirusによる重症熱の非構造蛋白質はSTAT2を標的とし,STAT1ではなく,I型インターフェロン刺激JAK-STATシグナル伝達を阻害する【JST・京大機械翻訳】

Author (7)： Kitagawa Yoshinori (Division of Microbiology and Infectious Diseases, Department of Pathology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan) ,  Sakai Madoka (Division of Microbiology and Infectious Diseases, Department of Pathology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan) ,  Sakai Madoka (Department of Microbiology, Faculty of Bio-Science, Nagahama Institute of Bio-Science and Technology, 1266 Tamura-cho, Nagahama, Shiga, 526-0829, Japan) ,  Shimojima Masayuki (Department of Virology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan) ,  Saijo Masayuki (Department of Virology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan) ,  Itoh Masae (Department of Microbiology, Faculty of Bio-Science, Nagahama Institute of Bio-Science and Technology, 1266 Tamura-cho, Nagahama, Shiga, 526-0829, Japan) ,  Gotoh Bin (Division of Microbiology and Infectious Diseases, Department of Pathology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan)
Material： Microbes and Infection  (Microbes Infect)
Volume： 20  Issue： 6  Page： 360-368  Publication year： 2018 
JST Material Number： E0586C  ISSN： 1286-4579  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The nonstructural protein NSs ...

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Thesaurus term： immunoprecipitation ,  interferon gamma ,  cytoplasm ,  *interferon ,  phosphorylation ,  *STAT transcription factor ,  *thrombocytopenia ,  subcellular distribution ,  interaction ,  *protein
Semi thesaurus term： 核内移行 ,  チロシンリン酸化 ,  再配列 ,  遮断 ,  *重症 , 【Automatic Indexing@JST】

Author keywords (6)： SFTSV ,  NSs ,  Interferon ,  JAK-STAT pathway ,  STAT2 ,  Inclusion body

JST classification (2)： Cell physiology in general  (EF02010S) ,  Cytokines  (EB08090G)

Terms in the title (13)： 血小板減少 ,  症候群 ,  重症 ,  構造蛋白質 ,  STAT2 ,  標的 ,  STAT1 ,  I型インターフェロン ,  刺激 ,  JAK ,  Stat ,  シグナル伝達 ,  阻害