Art

J-GLOBAL ID：201802258182005982   Reference number：18A1141373

Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells

上皮および間葉様食道扁平上皮癌細胞に対するEGFR阻害剤の異なる効果【JST・京大機械翻訳】

Author (16)： Yoshioka Masahiro (Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Yoshioka Masahiro (Department of Therapeutic Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Ohashi Shinya (Department of Therapeutic Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Ida Tomomi (Department of Therapeutic Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Nakai Yukie (Department of Therapeutic Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Kikuchi Osamu (Department of Therapeutic Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Kikuchi Osamu (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA) ,  Amanuma Yusuke (Department of Therapeutic Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Matsubara Junichi (Department of Therapeutic Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Yamada Atsushi (Department of Therapeutic Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Miyamoto Shin'ichi (Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Natsuizaka Mitsuteru (Department of Gastroenterology and Hepatology, Hokkaido University Hospital, Sapporo, Japan) ,  Nakagawa Hiroshi (Gastroenterology Division, Department of Medicine, University of Pennsylvania, Philadelphia, USA) ,  Chiba Tsutomu (Kansai Electric Power Hospital, Osaka, Japan) ,  Seno Hiroshi (Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Muto Manabu (Department of Therapeutic Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan)
Material： Journal of Experimental & Clinical Cancer Research (Web)
Volume： 36  Issue： 1  Page： 101  Publication year： 2017 
JST Material Number： U7514A  ISSN： 1756-9966  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Background Epidermal growth fa...

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Thesaurus term： *epithelium ,  phosphorylation ,  tumor ,  antitumor action ,  epithelial cell ,  gene ,  pathophysiology ,  EGF receptor ,  cell proliferation ,  heterotrans plantation ,  cell differentiation ,  human(primates) ,  Western blotting ,  phenotype ,  cell cycle

Author keywords (5)： Esophageal squamous cell carcinoma ,  EGFR inhibitor ,  Cell differentiation ,  Epithelial-like cell ,  Mesenchymal-like cell

JST classification (2)： Tumors(=neoplasms)of digestive system  (GH04000D) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Reference (38)：

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• Nat Cell Biol; EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer; V Kolev, A Mandinova, J Guinea-Viniegra, B Hu, K Lefort, C Lambertini, V Neel, R Dummer, EF Wagner, GP Dotto; 10; 2008; 902-911; 10.1038/ncb1750; CR2;
• J Biol Chem; Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo; CD Andl, T Mizushima, H Nakagawa, K Oyama, H Harada, K Chruma, M Herlyn, AK Rustgi; 278; 2003; 1824-1830; 10.1074/jbc.M209148200; CR3;
• J Dermatol Sci; Recent advances in the epidermal growth factor receptor/ligand system biology on skin homeostasis and keratinocyte stem cell regulation; D Nanba, F Toki, Y Barrandon, S Higashiyama; 72; 2013; 81-86; 10.1016/j.jdermsci.2013.05.009; CR4;
• Ann Thorac Surg; Epidermal growth factor receptor is a prognosis predictor in patients with esophageal squamous cell carcinoma; W Zhang, H Zhu, X Liu, Q Wang, X Zhang, J He, K Sun, X Liu, Z Zhou, N Xu, Z Xiao; 98; 2014; 513-519; 10.1016/j.athoracsur.2014.03.015; CR5;

Terms in the title (5)： 上皮 ,  間葉 ,  食道扁平上皮癌 ,  細胞 ,  EGFR阻害剤