Art

J-GLOBAL ID：201802259004240795   Reference number：18A0927466

Determining an optimal dose of linaclotide for use in Japanese patients with irritable bowel syndrome with constipation: A phase II randomized, double-blind, placebo-controlled study

便秘を伴う過敏性腸症候群の日本人患者における使用のためのリナacloの最適用量の決定:第II相無作為化二重盲検プラセボ対照試験【JST・京大機械翻訳】

Author (9)： Fukudo S. (Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Nakajima A. (Department of Gastroenterology, Yokohama City University, Yokohama, Japan) ,  Fujiyama Y. (Shiga University of Medical Science, Ohtsu, Japan) ,  Kosako M. (Japan-Asia Clinical Development 2, Development, Astellas Pharma Inc., Tokyo, Japan) ,  Nakagawa A. (Japan-Asia Clinical Development 2, Development, Astellas Pharma Inc., Tokyo, Japan) ,  Akiho H. (Japan-Asia Clinical Development 2, Development, Astellas Pharma Inc., Tokyo, Japan) ,  Nakashima Y. (Japan-Asia Data Science, Development, Astellas Pharma Inc., Tokyo, Japan) ,  Johnston J. M. (Ironwood Pharmaceuticals Inc., Cambridge, MA, USA) ,  Miwa H. (Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan)
Material： Neurogastroenterology & Motility
Volume： 30  Issue： 5  Page： e13275  Publication year： 2018 
JST Material Number： W2694A  ISSN： 1350-1925  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： BACKGROUND: Clinical testing t...

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Thesaurus term： abdominalgia ,  *irritable bowel syndrome ,  *constipation ,  man ,  *placebo ,  *patient ,  evaluation criterion ,  *double blind test ,  woman
Semi thesaurus term： 有害事象 ,  不快 ,  エンドポイント ,  治療期間 ,  *至適投与量 ,  *日本人 , 【Automatic Indexing@JST】

Author keywords (5)： abdominal pain ,  constipation ,  guanylate cyclase C activator ,  linaclotide ,  stool consistency

JST classification (4)： Drug therapy(=pharmacotherapy)for digestive system diseases  (GH05020G) ,  Clinical medicine on digestive system in general  (GH01030P) ,  Basic research of drugs acting on digestive system  (GW09010Q) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Terms in the title (8)： 便秘 ,  過敏性腸症候群 ,  日本人 ,  患者 ,  最適用量 ,  第II相 ,  二重盲検 ,  プラセボ