Art

J-GLOBAL ID：201802259508064657   Reference number：18A2058027

Shikonin Suppresses Lymphangiogenesis via NF-κB/HIF-1α Axis Inhibition

シコニンはNF-κB/HIF-1α軸阻害を介してリンパ管新生を抑制する

Author (5)： Prangsaengtong Orawin (Department of Biopharmacy, Faculty of Pharmacy, Srinakharinwirot University) ,  Jantaree Phatcharida (Laboratory of Biochemistry, Chulabhorn Research Institute) ,  Lirdprapamongkol Kriengsak (Laboratory of Biochemistry, Chulabhorn Research Institute) ,  Svasti Jisnuson (Laboratory of Biochemistry, Chulabhorn Research Institute) ,  Koizumi Keiichi (Department of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 41  Issue： 11  Page： 1659-1666(J-STAGE)  Publication year： 2018 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： HIF-1 alpha ,...

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Author keywords (10)： shikonin ,  lymphangiogenesis ,  nuclear factor-kappaB (NF-κB) ,  hypoxia-inducible factor-1 (HIF-1) ,  in vitro ,  shikonin ,  lymphangiogenesis ,  nuclear factor-kappaB (NF-κB) ,  hypoxia-inducible factor-1 (HIF-1) ,  in vitro

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Vasculature  (EJ04030O)

Substance index (2)： Shikonin ,  BAY-11-7085

Reference (39)：

• 1) Mäkinen T, Norrmen C, Petrova TV. Molecular mechanisms of lymphatic vascular development. Cell. Mol. Life Sci., 64, 1915-1929 (2007).
• 2) Karaman S, Detmar M. Mechanisms of lymphatic metastasis. J. Clin. Invest., 124, 922-928 (2014).
• 3) Stacker SA, Achen MG. From anti-angiogenesis to anti-lymphangiogenesis: emerging trends in cancer therapy. Lymphat. Res. Biol., 6, 165-172 (2008).
• 4) Assimopoulou AN, Boskou D, Papageorgiou VP. Antioxidant activities of alkannin, shikonin and Alkanna tinctoria root extracts in oil substrates. Food Chem., 87, 433-438 (2004).
• 5) Su L, Liu L, Wang Y, Yan G, Zhang Y. Long-term systemic toxicity of shikonin derivatives in Wistar rats. Pharm. Biol., 52, 486-490 (2014).

Terms in the title (5)： シコニン ,  NF-κB ,  HIF-1α ,  阻害 ,  リンパ管新生