Art

J-GLOBAL ID：201802260161268681   Reference number：18A1504115

Second-Generation SYK Inhibitor Entospletinib Ameliorates Fully Established Inflammation and Bone Destruction in the Cherubism Mouse Model

第二世代SYK阻害剤エントスプライチニブは,cherubマウスモデルにおいて完全に確立された炎症および骨破壊を改善する【JST・京大機械翻訳】

Author (9)： Yoshimoto Tetsuya (Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City (UMKC), MO, USA) ,  Hayashi Tatsuhide (Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City (UMKC), MO, USA) ,  Hayashi Tatsuhide (Department of Dental Materials Science, Aichi Gakuin University School of Dentistry, Nagoya, Japan) ,  Kondo Toshio (Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City (UMKC), MO, USA) ,  Kondo Toshio (Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan) ,  Kittaka Mizuho (Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City (UMKC), MO, USA) ,  Reichenberger Ernst J (Department of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT, USA) ,  Ueki Yasuyoshi (Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City (UMKC), MO, USA) ,  Ueki Yasuyoshi (Center of Excellence in the Study of Dental and Musculoskeletal Tissues (CEMT), University of Missouri-Kansas City (UMKC), Kansas City, MO, USA)
Material： Journal of Bone and Mineral Research  (JBMR)
Volume： 33  Issue： 8  Page： 1513-1519  Publication year： 2018 
JST Material Number： W1633A  ISSN： 0884-0431  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Cherubism is a craniofacial di...

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Thesaurus term： TNF alpha ,  swelling(disease) ,  variation(biology) ,  mandible ,  myeloid cell ,  human(primates) ,  administration(biology) ,  phenotype ,  neonate ,  patient ,  serum ,  *inflammation
Semi thesaurus term： 疾患進行 ,  発症 ,  *阻害剤 , 【Automatic Indexing@JST】

Author keywords (6)： CHERUBISM ,  SH3BP2 ,  SYK ,  ENTOSPLETINIB/GS-9973 ,  AUTOINFLAMMATION ,  BONE DESTRUCTION

JST classification (2)： Cell physiology in general  (EF02010S) ,  Basic medicine on musculoskeletal system  (GG01020B)

Terms in the title (6)： 世代 ,  Syk ,  阻害剤 ,  マウスモデル ,  炎症 ,  骨破壊