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J-GLOBAL ID：201802260866321510   Reference number：18A0392558

Parkin promotes proteasomal degradation of synaptotagmin IV by accelerating polyubiquitination

パーキンはポリユビキチン化を促進することによりシナプトタグミンIVのプロテアソーム分解を促進する【Powered by NICT】

Author (6)： Kabayama Hiroyuki (Laboratory for Developmental Neurobiology, Brain Science Institute, Institute of Physical and Chemical Research (RIKEN), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan) ,  Tokushige Naoko (Laboratory for Developmental Neurobiology, Brain Science Institute, Institute of Physical and Chemical Research (RIKEN), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan) ,  Takeuchi Makoto (Laboratory for Developmental Neurobiology, Brain Science Institute, Institute of Physical and Chemical Research (RIKEN), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan) ,  Kabayama Miyuki (Division of Functional Morphology, Department of Basic Veterinary Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonantyo, Musashino, Tokyo 180-8602, Japan) ,  Fukuda Mitsunori (Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai, Miyagi 980-8578, Japan) ,  Mikoshiba Katsuhiko (Laboratory for Developmental Neurobiology, Brain Science Institute, Institute of Physical and Chemical Research (RIKEN), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan)
Material： Molecular and Cellular Neuroscience  (MCN)
Volume： 80  Page： 89-99  Publication year： 2017 
JST Material Number： W0279A  ISSN： 1044-7431  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Parkin is an E3 ubiquitin liga...

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Thesaurus term： synapse ,  corpus striatum ,  phenotype ,  human(primates) ,  homology(characteristic) ,  *protein ,  neuron ,  PC12 cell ,  exocytosis ,  interaction ,  depolarization(physiology) ,  Parkinson's disease ,  catecholamine ,  primary amine
Semi thesaurus term： 神経変性 ,  *Parkin , 【Automatic Indexing@JST】

Author keywords (5)： Parkinson’s disease ,  Syt IV ,  Proteasomal degradation ,  Polyubiquitination ,  Evoked exocytosis regulator

JST classification (2)： Biological function  (EB03040U) ,  Basic neurology  (GN01020W)

Substance index (1)： Dopamine

Terms in the title (4)： パーキン ,  ポリユビキチン化 ,  促進 ,  プロテアソーム分解