Art

J-GLOBAL ID：201802261691172879   Reference number：18A2014183

Isocitrate dehydrogenase 1 mutation sensitizes intrahepatic cholangiocarcinoma to the BET inhibitor JQ1

イソくえん酸デヒドロゲナーゼ1変異は肝内胆管癌をBET阻害剤JQ1に感受性にする

Author (13)： Fujiwara Hiroaki (Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Tateishi Keisuke (Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Kato Hiroyuki (Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Nakatsuka Takuma (Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Yamamoto Keisuke (Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Tanaka Yasuo (Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Ijichi Hideaki (Department of Clinical Nutrition Therapy, The University of Tokyo Hospital, Tokyo, Japan) ,  Takahara Naminatsu (Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Mizuno Suguru (Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Kogure Hirofumi (Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Matsubara Saburo (Department of Gastroenterology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan) ,  Nakai Yousuke (Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Koike Kazuhiko (Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan)
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 109  Issue： 11  Page： 3602-3610  Publication year： 2018 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： gene ,...
Semi thesaurus term： BETファミリー蛋白質 ,...

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Author keywords (5)： apoptosis ,  BET inhibitor ,  cholangiocarcinoma ,  IDH mutation ,  MYC

JST classification (2)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Tumors(=neoplasms)of digestive system  (GH04000D)

Substance index (1)： JQ-1

Terms in the title (5)： イソくえん酸デヒドロゲナーゼ ,  変異 ,  肝内胆管癌 ,  BET阻害剤 ,  感受性