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J-GLOBAL ID：201802262142254961   Reference number：18A0789506

Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes

564歳における体細胞超突然変異の欠如における全身性自己免疫の加速: ノッキングされた重鎖および軽鎖遺伝子による全身性ループスのマウスモデル【JST・京大機械翻訳】

Author (9)： McDonald Gabrielle (Department of Integrative Physiology and Pathobiology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine) ,  Medina Carlos O. (Department of Integrative Physiology and Pathobiology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine) ,  Pilichowska Monika (Department of Pathology and Laboratory Medicine, Tufts Medical Center) ,  Kearney John F. (Department of Microbiology, University of Alabama) ,  Shinkura Reiko (Department of Immunology, Nagahama Institute of Bioscience and Technology) ,  Selsing Erik (Department of Integrative Physiology and Pathobiology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine) ,  Wortis Henry H. (Department of Integrative Physiology and Pathobiology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine) ,  Honjo Tasuku (Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University) ,  Imanishi-Kari Thereza (Department of Integrative Physiology and Pathobiology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine)
Material： Frontiers in Immunology (Web)
Volume： 8  Page： 1094  Publication year： 2017 
JST Material Number： U7074A  ISSN： 1664-3224  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： 564Igi mice have knocked-in im...

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Thesaurus term： *gene ,  autoantibody ,  *light chain ,  *mutation ,  immunoglobulin G ,  pathogenicity ,  RNA ,  *autoimmunity ,  *heavy chain ,  antibody ,  *somatic cell ,  glomerulonephritis
Semi thesaurus term： 免疫グロブリン受容体 ,  免疫グロブリンクラススイッチ ,  クラススイッチ組換え , 【Automatic Indexing@JST】

Author keywords (8)： activation-induced cytidine deaminase ,  somatic hypermutation ,  class switch recombination ,  systemic lupus erythematosus ,  autoantibodies ,  pathogenic antibodies ,  B cell central tolerance ,  RNA-specific antibodies

JST classification (4)： Immunological reaction in general  (ED03010T) ,  Antigens,antibodies,complements in general  (ED04010A) ,  Biochemistry of antigens,antibodies,complements  (ED04020L) ,  Molecular genetics in general  (EC02010J)

Terms in the title (12)： 体細胞 ,  突然変異 ,  欠如 ,  全身 ,  自己免疫 ,  加速 ,  ノッキング ,  重鎖 ,  軽鎖 ,  遺伝子 ,  ループス ,  マウスモデル