Art

J-GLOBAL ID：201802262455213636   Reference number：18A0975510

Poly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cells

ポリ(ADP-リボース)ポリメラーゼ阻害剤は神経幹/前駆細胞におけるp53シグナル伝達経路を活性化する【JST・京大機械翻訳】

Author (13)： Okuda Akiko (Laboratory of Pathophysiology and Pharmacotherapeutics, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan) ,  Okuda Akiko (Niigata University Graduate School of Health Sciences, Niigata, Japan) ,  Kurokawa Suguru (Laboratory of Pathophysiology and Pharmacotherapeutics, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan) ,  Takehashi Masanori (Laboratory of Pathophysiology and Pharmacotherapeutics, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan) ,  Maeda Aika (Laboratory of Pathophysiology and Pharmacotherapeutics, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan) ,  Fukuda Katsuya (Laboratory of Pathophysiology and Pharmacotherapeutics, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan) ,  Kubo Yukari (Laboratory of Pathophysiology and Pharmacotherapeutics, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan) ,  Nogusa Hyuma (Laboratory of Pathophysiology and Pharmacotherapeutics, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan) ,  Takatani-Nakase Tomoka (Laboratory of Pathophysiology and Pharmacotherapeutics, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan) ,  Takatani-Nakase Tomoka (Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Japan) ,  Okuda Shujiro (Bioinformatics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan) ,  Ueda Kunihiro (Kobe Tokiwa University, Kobe, Japan) ,  Tanaka Seigo (Laboratory of Pathophysiology and Pharmacotherapeutics, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan)
Material： BMC Neuroscience (Web)
Volume： 18  Issue： 1  Page： 14  Publication year： 2017 
JST Material Number： U7309A  ISSN： 1471-2202  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Background Poly(ADP-ribose) po...

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Thesaurus term： Apoptosis ,  substrate (biochemistry) ,  *p53 protein ,  DNA microarray ,  mRNA ,  Up-Regulation ,  gene ,  therapy ,  phosphorylation ,  DNA Repair ,  MEF cell ,  PARP inhibitor ,  Poly (ADP-Ribose) Polymerase-1 ,  *committed stem cell
Semi thesaurus term： *阻害剤 , 【Automatic Indexing@JST】

Author keywords (6)： Poly(ADP-ribosyl)ation ,  Poly(ADP-ribose) polymerase ,  Neural stem/progenitor cells ,  p53 ,  Cell cycle ,  Apoptosis

JST classification (2)： Cell physiology in general  (EF02010S) ,  Enzyme in general  (EB09010D)

Reference (64)：

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• Mol Cell; The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets; R Krishnakumar, WL Kraus; 39; 2010; 8-24; 10.1016/j.molcel.2010.06.017; CR2;
• J Biol Chem; Identification of potential active-site residues in the human poly(ADP-ribose) polymerase; F Simonin, O Poch, M Delarue, G Murcia; 268; 1993; 8529-8535; CR3;
• Mutat Res; Poly(ADP-ribose) catabolism in mammalian cells exposed to DNA-damaging agents; R Alvarez-Gonzalez, FR Althaus; 218; 1989; 67-74; 10.1016/0921-8777(89)90012-8; CR4;
• J Biol Chem; Stimulation of poly(ADP-ribosyl)ation during Ehrlich ascites tumor cell “starvation” and suppression of concomitant DNA fragmentation by benzamide; K Wielckens, E George, T Pless, H Hilz; 258; 1983; 4098-4104; CR5;

Terms in the title (8)： ADP ,  リボース ,  ポリメラーゼ阻害剤 ,  神経 ,  幹 ,  前駆細胞 ,  p53シグナル伝達経路 ,  活性化