Art

J-GLOBAL ID：201802262969332348   Reference number：18A1039039

Decarboxylation of indomethacin induced by heat treatment

熱処理により誘導されるインドメタシンの脱炭酸【JST・京大機械翻訳】

Author (11)： Shimada Yohsuke (Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan) ,  Shimada Yohsuke (Center for Drug Delivery Research, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan) ,  Komaki Haruki (Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan) ,  Hirai Ayako (Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan) ,  Goto Satoru (Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan) ,  Goto Satoru (Center for Drug Delivery Research, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan) ,  Hashimoto Yasuyuki (Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan) ,  Uchiro Hiromi (Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan) ,  Uchiro Hiromi (Center for Drug Delivery Research, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan) ,  Terada Hiroshi (Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan) ,  Terada Hiroshi (Center for Drug Delivery Research, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan)
Material： International Journal of Pharmaceutics  (Int J Pharm)
Volume： 545  Issue： 1-2  Page： 51-56  Publication year： 2018 
JST Material Number： A0285B  ISSN： 0378-5173  CODEN： IJPHD  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： As crystalline indomethacin is...

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Thesaurus term： amorphous state ,  coloring matter ,  glass ,  oxygen deficiency ,  heating temperature ,  *heat treatment ,  NMR ,  thermal decomposition ,  ultraviolet irradiation ,  *decarboxylation ,  degradation product ,  ring-opening reaction ,  oxidation ,  nitrogen heterocyclic compound ,  polynuclear aromatic compound ,  aromatic carboxylic acid ,  enzyme inhibitor ,  aromatic chlorine compound ,  carboxamide ,  phenol ether

Author keywords (5)： Indomethacin ,  Amorphous ,  Decarboxylation ,  NMR ,  EI-MS

JST classification (1)： Physical pharmacy  (GY01012A)

Substance index (2)： Indole ,  Indomethacin

Terms in the title (4)： 熱処理 ,  誘導 ,  インドメタシン ,  脱炭酸