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J-GLOBAL ID：201802263030590460   Reference number：18A1591860

Chemical chaperone 4-phenylbutylate reduces mutant protein accumulation in the endoplasmic reticulum of arginine vasopressin neurons in a mouse model for familial neurohypophysial diabetes insipidus

化学シャペロン4-フェニルブチル酸は家族性神経下垂体性尿崩症のマウスモデルにおけるアルギニンバソプレシンニューロンの小胞体における変異蛋白質蓄積を減少させる【JST・京大機械翻訳】

Author (15)： Tochiya Masayoshi (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan) ,  Hagiwara Daisuke (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan) ,  Azuma Yoshinori (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan) ,  Miyata Takashi (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan) ,  Morishita Yoshiaki (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan) ,  Suga Hidetaka (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan) ,  Onoue Takeshi (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan) ,  Tsunekawa Taku (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan) ,  Takagi Hiroshi (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan) ,  Ito Yoshihiro (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan) ,  Iwama Shintaro (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan) ,  Iwama Shintaro (Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya, 464-8601, Japan) ,  Goto Motomitsu (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan) ,  Banno Ryoichi (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan) ,  Arima Hiroshi (Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan)
Material： Neuroscience Letters  (Neurosci Lett)
Volume： 682  Page： 50-55  Publication year： 2018 
JST Material Number： W0118A  ISSN： 0304-3940  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Familial neurohypophysial diab...

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Thesaurus term： *Diabetes Insipidus ,  *pituitary gland ,  *Endoplasmic Reticulum ,  *neuron ,  dominance ,  *Proteins ,  Phenotype ,  autosome ,  mouse model ,  *Nerve ,  *Genetic Variation ,  vasopressin
Semi thesaurus term： genetic variation ,  *variation(biology) ,  多尿症 ,  中枢性尿崩症 , 【Automatic Indexing@JST】

Author keywords (5)： Familial neurohypophysial diabetes insipidus (FNDI) ,  4-Phenylbutylate (4-PBA) ,  Endoplasmic reticulum (ER) stress ,  Endoplasmic reticulum-associated compartment (ERAC) ,  Arginine vasopressin (AVP)

JST classification (2)： Molecular genetics in general  (EC02010J) ,  Basic medicine on urogenital system  (GM01020T)

Substance index (1)： Arginine Vasopressin

Terms in the title (10)： 化学シャペロン ,  酸 ,  家族 ,  神経 ,  下垂体性尿崩症 ,  マウスモデル ,  小胞体 ,  変異 ,  蛋白質 ,  蓄積