Art

J-GLOBAL ID：201802263232165967   Reference number：18A0362779

Tacrolimus Dose Optimization Strategy for Refractory Ulcerative Colitis Based on the Cytochrome P450 3A5 Polymorphism Prediction Using Trough Concentration after 24 Hours

24時間後のトラフ濃度を用いたチトクロームP450 3A5多型性予想に基づく難治性潰瘍性大腸炎に対するタクロリムスの用量最適化戦略

Author (12)： ONODERA Motoyuki (Tohoku Univ. Graduate School of Medicine, Miyagi, JPN) ,  ENDO Katsuya (Tohoku Medical and Pharmaceutical Univ., Miyagi, JPN) ,  NAITO Takeo (Tohoku Univ. Graduate School of Medicine, Miyagi, JPN) ,  MOROI Rintaro (Tohoku Univ. Graduate School of Medicine, Miyagi, JPN) ,  KUROHA Masatake (Tohoku Univ. Graduate School of Medicine, Miyagi, JPN) ,  KANAZAWA Yoshitake (Tohoku Univ. Graduate School of Medicine, Miyagi, JPN) ,  KIMURA Tomoya (Tohoku Univ. Graduate School of Medicine, Miyagi, JPN) ,  SHIGA Hisashi (Akita Univ. Graduate School of Medicine, Akita, JPN) ,  KAKUTA Yoichi (Tohoku Univ. Graduate School of Medicine, Miyagi, JPN) ,  NEGORO Kenichi (Tohoku Univ. Graduate School of Medicine, Miyagi, JPN) ,  KINOUCHI Yoshitaka (Tohoku Univ., Miyagi, JPN) ,  SHIMOSEGAWA Tooru (Tohoku Univ. Graduate School of Medicine, Miyagi, JPN)
Material： Digestion
Volume： 97  Issue： 1  Page： 90-96  Publication year： 2018 
JST Material Number： E0535B  ISSN： 0012-2823  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Thesaurus term： *ulcerative colitis ,...
Semi thesaurus term： *Intractable ulcerative colitis ,...

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JST classification (3)： Clinical application of immunotherapeutic agents and blood preparations  (GW22020O) ,  Clinical biopharmacy  (GY01022L) ,  Drug therapy(=pharmacotherapy)for digestive system diseases  (GH05020G)

Substance index (1)： Tacrolimus

Terms in the title (9)： トラフ濃度 ,  チトクロームP450 ,  多型性 ,  予想 ,  難治性潰瘍性大腸炎 ,  タクロリムス ,  用量 ,  最適化 ,  戦略